Specimen

Serum

Collection Medium:

Minimum:

Adult minimum: 3.5 mL serum
Pediatric minimum: 1.5 mL serum
This volume does not permit repeat analysis.

Analytic Time:

2 weeks

Reference Range:

ALDOSTERONE, Serum:   Values are based on early morning samples from 
subjects on ad lib sodium intake.  Diurnal variations and values in 
pediatric patients on different sodium diets are currently unavailable.
                          Supine                       Upright
                   Range        Mean           Range         Mean
                   (ng/dl)     (ng/dl)        (ng/dl)       (ng/dl)
Premature Infants:
 26-28 weeks, Day 4  5-635        192                not applicable
 31-35 weeks, Day 4 19-141        100                not applicable
Full-term infants:
 3 Days:             7-184         95                not applicable
 1 Week:             5-175         46                not applicable
 1-12 Months:        5-90          31                not applicable
Children:
 1-2 Years:          7-54          28                not applicable
 2-10 Years:         3-35          11           5-80           28
10-15 Years:         2-22           5           4-48           20
Adults:              3-16           7           7-30           13

CORTICOSTERONE
                          Range        Mean
                         (ng/dl)      (ng/dl)
Premature Infants:
 26-28 weeks, Day 4      235-1108       560
 31-35 weeks, Day 4      150-1700       680
Newborn:
 1-7  Days:               70-850        230
 1-12 Months:             80-1500       545

                   Range      Mean            Range     Mean
                  (ng/dl)    (ng/dl)         (ng/dl)   (ng/dl)
                        8:00 a.m.                 4:00 p.m.
Children:
 1-16 Years:      135-1860     460            70-620    180
Adults:           130-820      425            60-220    130

18-HYDROXYCORTICOSTERONE
Samples were collected without regard to posture from subject on ad lib 
sodium intake.  For additional informationon the effects of posture and 
sodium intake, contact the Endocrine Sciences Laboratory 800-444-9111.

                      18-OH-CORTICOSTERONE       18-OH-CORTICOSTERONE/
                                                  ALDOSTERONE   RATIO
                       Range        Mean          Range          Mean
                      (ng/dl)      (ng/dl)       (ng/dl)        (ng/dl)
Premature Infants:
 26-28 Weeks, Day 4:  10-670         218         1.0-4.5          1.2
 31-35 Weeks, Day 4:  57-410         202         1.1-5.2          2.2
Full-term Infants:
 3 Days:              31-546         348         2.6-5.3          3.4
 1-12 Months:          5-220          81         2.3-6.0          2.7
Children:
 1-2 Years:           18-155          65         1.7-5.0          3.0
 2-10 Years:           6-85           44         2.4-10.5         3.3
 10-15 Years:         10-72           25         2.0-8.3          3.4
Adults:                9-58           23         1.7-8.8          3.0

DEOXYCORTICOSTERONE (DOC)
                        Range         Mean
                       (ng/dl)       (ng/dl)
Premature Infants:
 26-28 Weeks, Day 4:    20-105         47
Newborn:  Levels are markedly elevated at birth and decrease rapidly 
during the first week to the range found in older infants.
Full-term Infants:
 1-12 Months:            7-49          23
Prepubertal Children:
 2-10 Years:             2-34          10.9
Pubertal Children and Adults:
 8:00 a.m.               2-19           7.1

Methodology:

Aldosterone methodology:  RIA after selective solvent extraction
Corticosterone methodology:  RIA after selective solvent extraction
18-Hydroxycorticosterone methodology:  RIA after paper chromatography
Deoxycorticosterone (DOC)methodology:  RIA after HPLC

CPT Code:

Please use Mineralcorticoid Profile for Pediatric patients only.  
Includes:82088 Aldosterone, Serum; 82528 Corticosterone, Serum; 83542 
18-Hydroxycorticosterone, Serum; 82633 Deoxycorticosterone (DOC), Serum

See also:
18-Hydroxycorticosterone, Serum
Deoxycorticosterone, Serum