The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Thiopurine Methyltransferase, RBC
Order Code: TPMT
Order Form: A-1a Miscellaneous Request or IPR Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen
 
Whole Blood
Collection Medium:
Green top tube (Na Heparin) 


Minimum:


5.0 mls whole blood


Rejection Criteria:


Collect Monday through Thursday only; do not collect on Fridays, 
holidays, day before a holiday, or weekends.  Sample older than 72 hrs.


Analytic Time:


2 weeks


Reference Range:


15.1 - 26.4 U/ml RBC  Normal
 6.3 - 15.0 U/ml RBC  Heterozygous for low Thiopurine Methyltransferase
<6.3        U/ml RBC  Homozygous for low Thiopurine Methyltransferase


Methodology:


Enzymatic End-Point/Liquid Chromatography - Tandem Mass Spectrometry 
(LC-MS/MS)


CPT Code:


83789




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Updated: 08/12/2008

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.