The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Histone Antibody, IgG
Order Code: HIST
Order Form: A-1a Miscellaneous Request or IPR Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen
 
Serum
Collection Medium:
Red top tube 


Minimum:


Recommended minimum: 1 mL serum
Absolute minimum:    0.5 mL serum
Pediatric minimum:   0.15 mL serum


Rejection Criteria:


Hemolyzed or lipemic specimens.


Analytic Time:


4 working days


Reference Range:


None detected:   < 1.0 Units
Inconclusive:    1.0 - 1.5 Units
Positive:        1.6 - 2.5 Units
Strong positive: > 2.5 Units


Test
Limitations:


Histone antibodies are present in 20-55% of idiopathic systemic lupus 
erythematosus (SLE) and 80-95% of drug-induced SLE.  They occur in less 
than 20% of other types of connective tissues diseases.


Methodology:


Enzyme-Linked Immunosorbent Assay


CPT Code:


83516




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Updated: 05/16/2007

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.