The Auditory Physiology Laboratory

National Institute of Health
Quarterly Progress Reports

Neural Prosthesis Program Progress Reports

Neural Prosthesis Program Contract N01-DC-6-2111 (1997-1999)

Neurophysiological Effects of Simulated Auditory Prosthesis Stimulation

P.J. Abbas and J.T. Rubinstein, Co-Principal Investigators
C.A. Miller, Assistant Research Scientist

Report	Date	Focus topic
1	Jan. 29, 1997	Basic properties of the ECAP Single fiber and model results
2	May. 27, 1997	Properties of the refractory ECAP Membrane noise and ECAP growth Implications for speech processors
3	Jul. 28, 1997	Single-fiber response properties: Group trends Single-fiber response properties: Additional observations
4	Oct. 30, 1997	Two-pulse stimuli – temporal interactions Constant-amplitude pulse train data Amplitude modulation of pulse trains
5	Jan. 31., 1998	Pseudospontaneous activity
6	Apr. 30, 1998	Response properties of electrically stimulated auditory nerve Preliminary results of ongoing work
7	Jul. 29, 1998	Compound action potentials evoked by electrical pulse trains: Effects of stimulus parameters on response pattern
8	Oct. 27, 1998	Pseudospontaneous activity
9	Jan. 26, 1999	Analysis of single-fiber data A phenomenological model of the ECAP
10	May 1, 1999	Compound action potential in response to amplitude modulated pulse trains
11	Jul. 31, 1999	Pseudospontaneous activity: Further analysis Clinical applications
Final	Nov. 1, 1999	Characteristics of the ECAP Characteristic of single-unit responses Modeling studies Human studies

Neural Prosthesis Program Contract N01-DC-9-2107 (2000-2003)

Neurophysiological Effects of Simulated Auditory Prosthesis Stimulation

PJ Abbas and JT Rubinstein, Co-Principal Investigators
CA Miller. Investigator
H Mino, Associate Research Scientist

Report	Date	Focus topic
1	Jan 31, 2000	An improved method for obtaining ECAP refractory data
2	Apr. 30, 2000	Examination of responses to monophasic, biphasic, and pseudomonophasic stimulus pulses
3	Jul. 31, 2000	Monophasic and biphasic thresholds and latencies
4	Oct. 31, 2000	Examination of ECAP responses to sinusoidal electrical stimulation with and without high-rate pulses
5	Jan. 31., 2001	Response properties of the refractory auditory nerve fiber
6	Apr. 30, 2001	Preliminary results of experiments with University of Michigan thin-film recording electrodes
7	Jul. 31, 2001	Effects of the electrode-to-fiber distance on neural responses
8	Oct. 31, 2001	Adaptation in response to electrical stimulation of the deafened cochlea Conditioning pulses in human subjects
9	Jan. 31, 2002	Effects of electrode configuration on the ensemble response of the nerve
10	Apr. 30, 2002	Conditioning pulses in human subjects
11	Jul. 31, 2002	How can refractoriness influence spike initiations?
12	Apr. 2003	Effect of recording electrode position on the electrically evoked compound action potential
Final	Oct 2003	Responses to monopolar, monophasic stimuli Responses to biphasic and pseudomonophasic stimuli Refractory properties of auditory nerve fibers Responses to electric pulse train stimuli Spread of excitation / channel interaction Effects of stimulus electrode configuration on neural excitation Effects of recording site on the ECAP Feasibility of thin-film recordings from the auditory nerve

Neural Prosthesis Program Contract N01-DC-2-1005 (2002-)

Effects of Remaining Hair Cells on Cochlear Implant Function

PJ Abbas, Principal Investigator

Report	Date	Focus topic
1	Oct. 31, 2002	The effects of furosemide on the electrically evoked compound action potential
2	Jan. 31, 2003	Acoustic/electric stimulus interactions at the single-fiber level: initial findings
3	Apr. 30, 2003	Effects of acoustic noise on the ECAP responses to pulse trains
4	July 31, 2003	Effects of acoustic noise on single-fiber responses to single electric pulses
5	Oct. 31, 2003	Quantitative analysis of acoustic-electric interactions during stimulation with electric pulse trains
6	Jan. 30, 2004	Acoustic-electric interactions observed at the single-fiber level using longer-duration stimuli
7	April 30, 2004
8	July 30, 2004
9	Oct. 30, 2004
10	Jan. 31, 2005	Simultaneous and forward masking of the ECAP by acoustic noise and high-rate electric pulse trains
11	April 30, 2005
12	July 27, 2005	Single-fiber measures of electric responses in acoustically sensitive ears
13	Oct. 31, 2005	Forward masking of the electrically evoked compound action potential following furosemide treatment
14	Jan. 30, 2006	Single-fiber measurements of electric forward masking
15	April 30, 2006	Model for combined electric and acoustic stimulation of the auditory nerve fiber
16	July 27, 2006	Single fiber electric adaptation and recovery relationship between cochlear place and electric threshold

Neural Prosthesis Program Contract N01-DC-9-2106 (1999-2002)

Effects of Remaining Hair Cells on Cochlear Implant Function

P.J. Abbas, Principal Investigator
C.A. Miller and J.T. Rubinstein, Co-investigators
H. Mino, Associate Research Scientist

Report	Date	Focus topic
1	Nov. 9, 1999
2	Feb. 29, 2000
3	Apr. 30, 2000	Comparison of ECAP before and after deafening
4	Jul. 31, 2000	Comparison of algorithms in generation of action potentials using stochastic models
5	Oct. 31, 2000	Electrically evoked responses before and after deafening The effect of the simultaneous presentation of acoustic and electric stimuli
6	Jan. 31, 2001
7	Apr. 30, 2001	Electrically evoked responses during and after stimulation with acoustic noise Electrically evoked responses with high-pass acoustic noise
8	Aug. 15, 2001	Development of a biophysical model for vestibular prosthesis research
9	Oct. 31, 2001	The binaural ABR response to combined acoustic and electric stimulation
10	Jan. 31, 2002	Auditory response to electric pulse trains before and after furosemide treatment
11	Apr. 30, 2002	Acoustic electric interactions in partially deafened animals
Final	Jul. 31, 2002	Effect of functional hair cells on the response to electrical stimulation Effect of acoustic stimulation on the responses to electrical stimulation Responses in ears with partial hearing loss