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The Laboratory of Neurobiology, led by Dr. William Talman, is located in research buildings at the Iowa City Department of Veterans Affairs Medical Center. Over the past 20 years it has been funded by grants from the Department of Veterans Affairs, the American Heart Association, and the Heart, Lung and Blood Institute of the National Institutes of Health. The seminal focus of the laboratory is the study of central autonomic control as it relates to regulation of the cardiovascular system. The laboratory integrates physiological, pharmacological, neurochemical, immunohistochemical, microscopy (light, confocal and electron microscopy), and molecular / cellular techniques to study neurotransmitter systems that may mediate transmission of signals at central synapses in cardiovascular reflex pathways.