Project 3: Therapeutic Potential of Embryonic Stem Cell-Derived Myogenic Precursors
PI: Dr. Baoli Yang
Dr. Yang is studying the development of embryonic stem cells as therapeutic tools for stem cell treatments.
This project is exploring the therapeutic potential of mouse embryonic stem (ES) cells, with the ultimate goal of discovering principles that govern the differentiation of ES cells into myogenic precursor cells that can be used in cell transplantation in murine models of MDs. Our results will enable methods for enhanced myogenic development from ES cells and reconstitution of the adult myogenic system as a model for myogenic research and cellular therapies. Future efforts will explore the similarities and differences in the myogenic potential of murine and human ES cells, and the therapeutic potential of in vitro differentiated human ES cells.