Project 1: Novel Therapeutic Strategies for Duchenne Muscular Dystrophy
PI: Dr. Kevin P. Campbell
Dr. Campbell is using mouse models to explore the therapeutic potential of improving muscle membrane maintenance and repair for the treatment of Duchenne muscular dystrophy.
This project is exploring the therapeutic potential of improving muscle cell membrane maintenance and repair for the treatment of Duchenne muscular dystrophy. We are investigating whether increased expression of LARGE or dysferlin produce functional and physiological improvement in muscle. Focusing on endogenous proteins like LARGE or dysferlin, whose activity could potentially be modulated, will provide a platform for new targets of therapy (possibly pharmacological treatments) aimed at upregulating LARGE or dysferlin expression and/or activity to treat Duchenne muscular dystrophy.
Dr. Campbell's Research Laboratory Website
Dr. Campbell's Department of Physiology & Biophysics Website