2008
Rodionov R and Lentz SR. The homocysteine paradox. Arterioscler Thromb Vasc Biol. (2008) Jun;28(6):1031-3
Dayal S, Rodionov RN, Arning E, Bottiglieri T, Kimoto M, Murry DJ, Cooke JP, Faraci FM, Lentz SR. Tissue-specific Downregulation of Dimethylarginine Dimethylaminohydrolase in Hyperhomocysteinemia. Am J Physiol Heart Circ Physiol (2008) Aug;295(2):H816-25.
Dayal S and Lentz SR. Murine Models of Hyperhomocysteinemia and Their Vascular Phenotypes.
Arterioscler Thromb Vasc Biol (2008) Sep;28(9):1596-605.
Dayoub H., Rodionov, R.N., Lynch, C., Cooke, J.P., Arning, E., Bottiglieri, T., Lentz, S.R., and Faraci, F.M. Overexpression of dimethylarginine dimethylaminohydrolase inhibits ADMA-induced endothelial dysfunction in the cerebral circulation. Stroke (2008) 39:180-184
Jobe, S.M., Wilson, K.M., Leo, L., Raimondi, A., Molkentin, J.D., Lentz, S.R., and Di Paola, J. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation. Blood (2008) 111:1257-1265
Chrissobolis, S., Didion, S.P., Kinzenbaw, D.A., Schrader, L.I., Dayal, S., Lentz, S.R., and Faraci, F.M. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension (in press)
Raife, T.J., Rose, J.S., and Lentz, S.R. Bleeding from acquired coagulation defects and antithrombotic therapy. In: Rossi’s Principles of Transfusion Medicine, 4th ed. (in press)
2007
Devlin, A.M., Boersma,H.M., Wade, R.E., Singh, R., Innis, S.M., Bottiglieri T., and Lentz, S.R. Reduced methylation capacity in mice with hyperhomocysteinemia is asssociated with altered hepatic fatty acid and phospholipid metabolism. J. Biol. Chem. (2007) 282:37082-37090
Tsimikas,S., Aikawa,M., Miller, F.J., Jr., Miller, E.R., Torzewski,M., Lentz, S.R., Bergmark, C., Heistad, D.D., Libby, P., and Witzum, J.L. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions following dietary lipid lowering: a potential biomarker of early atherosclerosis regression. Arterioscl. Thromb. Vasc. Biol. (2007) 27:175-181
Wilson, K.M., McCaw, R.B., Leo, L., Arning, E., Lhoták, Š., Bottiglieri, Austin, R.C., and Lentz, S.R. Prothrombotic effects of hypercholesterolemia and hyperhomocysteinemia in ApoE-deficient mice. Arterioscl. Thromb. Vasc. Biol. (2007) 27:233-240
Sontag, E., Nunbhakdi-Craig, V., Sontag, J.M., Diaz-Arrastia, R., Ogris, E., Dayal, S., Lentz, S.R., Arning, E, and Bottiglieri, T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and APP regulation. J. Neurosci. (2007) 27:2751-2759
Kitayama, J., Faraci, F.M., Lentz, S.R., and Heistad, D.D. Cerebral vascular dysfunction during hypercholesterolemia. Stroke (2007) 38:2136-2141
Vitvitsky, V., Prudova, A., Stabler, S., Dayal, S., Lentz, S.R., and Banerjee, R. Testosterone regulation of renal cystathionine β-synthase: implications for sex-dependent differences in plasma homocysteine levels. Am. J. Physiol. Renal Physiol. (2007) 293:F594-600
Lentz, S.R. Homocysteine. In: McGraw-Hill Encyclopedia of Science & Technology, 10th Edition. (2007)
Devlin, A.M. and Lentz, S.R. Hyperhomocysteinemia. In: Clinical Studies in Medical Biochemistry, 3rd Edition. Glew, R.H. and Rosenthal, M.D., editors. Oxford University Press (2007) 226-233
Dayal, S. and Lentz, S.R. Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals. Antioxid. Redox Signal. (2007) 9:1899-1909
2006
Devlin, A.M. and Lentz, S.R. Apo A-I: a missing link between homocysteine and lipid metabolism? Circ. Res. (2006) 98:431-433
Dayal, S., Wilson, K.M., Leo, L., Arning, E., Bottigliere, T., and Lentz, S.R. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. (2006); 108:2237-2243.
Symons, J.D., Zaid, U.B., Athanassious, C.N., Mullick, A.E., Lentz, S.R., and Rutledge, J.C. Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia. Arterioscl. Thromb. Vasc. Biol. (2006) 26:814-818
Fernández, J.A., Lentz, S.R., Dwyre, D.M., and Griffin, J.H. A novel ELISA for mouse activated protein C. J. Immunol. Method. (2006) 314:174-181
Mullick, A.E., Zaid, U.B., Athanassious, C.N., Lentz, S.R., Rutledge, J.C., and Symons, J.D. Hyperhomocysteinemia increases arterial permeability and stiffness in mice. Am. J. Physiol. (2006) 291:R1349-R1354
2005
Devlin, A.M., Bottiglieri, T., Domann, F.E., and Lentz, S.R. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J. Biol. Chem. (2005) 280:25506-25511
Dayal, S., Devlin, A.M., McCaw, R.B., Liu, M.L., Arning, E., Bottiglieri, T., Shane, B., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation (2005) 112:737-744
Jobe, S.M., Leo, L., Eastvold, J., Dickneite, G., Ratliff, T.L., Lentz, S.R., and Di Paola, J. Role of FcRγ and factor XIIIA in coated platelet formation. Blood (2005) 106:4146-4151
Wilson, K.M. and Lentz, S.R. Need for mechanical ventilation with murine thrombosis models (Letter). Thromb. Haemost. (2005) 93:389
Lentz, S.R. Another lesson from the factor V Leiden mouse: thrombin generation drives arterial disease. Circulation (2005) 111:1733-1734
Raife, T.J. and Lentz, S.R. The benefits of excess EPCR. J. Thromb. Haemost. (2005) 3:1349-1350
Lentz, S.R. Mechanisms of homocysteine-induced atherothrombosis. J. Thromb. Haemost. (2005) 3:1646-1654
Wilson, K.M. and Lentz, S.R. Mechanisms of the atherogenic effects of elevated homocysteine in experimental models. Sem. Vasc. Med. (2005) 5: 163-171
Dayal, S. and Lentz, S.R. ADMA and hyperhomocysteinemia. Vascular Medicine (2005) 10:S27-33
Lentz, S.R., Devlin, A.M., and Dayal, S. Endothelial dysfunction & homocysteine: studies in genetic models of moderate hyperhomocysteinemia in mice. (2005) In: Homocysteine Metabolism. Symposia Proceedings, 4th International Conference on Homocysteine Metabolism. Fowler, B. Ed. SPS Publications
2004
Dayal, S., Arning, E., Bottiglieri, T., Böger, R.H., Sigmund, C.D., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 35: 1957-1962
Devlin, A.M., Arning, E., Bottiglieri, T., Faraci, F.M., Rozen, R., and Lentz, S.R. Effect of MTHFR genotype on diet-induced hyperhomocysteinemia and vascular dysfunction in mice. Blood (2004) 103:2624-2629
Crist, S.A., Elzey, B.D., Ludwig, A.T., Griffith, T.S., Staack, J.B., Lentz, S.R., and Ratliff, T.L. Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. Exp. Hematol. (2004) 32:1073-1081
Vitvitsky, V., Dayal, S., Stabler, S., Wang, H., Lentz, S.R., and Banerjee, R. Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am. J. Physiol. (2004) 287:R39-R46
Zhou, J., Werstuck, G.H., Lhoták, Š., de Koning, A.B.L., Sood, S.K., Hossain, G.S., Møller, J., Ritskes-Hoitinga, M., Falk, E., Dayal, S., Lentz, S.R., and Austin, R.C. Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apoE-deficient mice. Circulation (2004) 110:207-213
Lentz, S.R. and Haynes, W.G. Homocysteine: a clinically important cardiovascular risk factor? Cleveland Clinic J. Med. (2004) 71:729-734
Austin, R.C., Lentz, S.R., and Werstuck, G.H. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Diff. (2004) 11:S56-S64
2003
Lentz, S.R. Thrombosis of vein grafts: wall tension restrains thrombomodulin expression. Circ. Res. 2003 Jan 10;92(1):12-3
Lentz, S.R. Homocysteine. In: McGraw-Hill Yearbook of Science & Technology. McGraw-Hill Companies, New York. (2003) 180-182
Slungaard, A., Fernández, J.A., Griffin, J.H., Key, N.L., Long, J.L., Piegors, D.J., and Lentz, S.R. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood, 2003; 102: 146-151.
Elzey, B.D., Tian, J., Jensen, R.J., Swanson, A.K., Lees, J.R., Lentz, S.R., Stein, C., Nieswandt, B., Wang, Y., Davidson, B., and Ratliff, T.L. Platelet-mediated modulation of adaptive immunity: a communication link between innate and adaptive immune compartments. Immunity (2003) 19:9-19.
Wilson, K.M., Lynch, C.M., Faraci, F.M., and Lentz, S.R. Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. J. Thromb. Haemost. (2003) 1:2669-2674.
Lentz, S.R., Rodionov, R.N., and Dayal, S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. Atherosclerosis (2003) Suppl. 4, 61-65.
Faraci, F.M. and Lentz, S.R. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke (2004) 35:345-347
2002
Raife, T.J., Lentz, S.R., Atkinson, B., Vesely, S.K., and Hessner, M.J. Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity. Blood (2002) 99:437-442
Rosenfeld, S.B., Watkinson, K.K., Thompson, B.H., Macfarlane, D.E., and Lentz, S.R. Pulmonary embolism after sequential use of recombinant factor VIIa and activated prothrombin complex concentrate in a factor VIII inhibitor patient. Thromb. Haemost. (2002) 87:925-926
Lentz, S.R., Miller, F.J., Jr., Piegors, D.J., Erger, R.A., Fernández, J.A., Griffin, J.H., and Heistad, D.D. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation (2002) 106:842-846
Lentz, S.R., Piegors, D.J., Fernández, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., and Heistad, D.D. Effect of hyperhomocysteinemia on protein C activation and activity. Blood (2002) 100:2108-2112
Leo, L., Di Paola, J., Judd, B.A., Koretzky, G.A., and Lentz, S.R. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood (2002) 100:2839-2844
Baumbach, G.L., Sigmund, C.D., Bottiglieri, T., Arning, E., and Lentz, S.R. Structure of cerebral arterioles in cystathionine b-synthase-deficient mice. Circ. Res. (2002) 91:931-937
Dayal, S., Brown, K.L, Weydert, C.J., Oberley, L.W., Arling, E., Bottiglieri, T., Faraci, F.M., and Lentz, S.R. Deficiency of glutathione peroxidase-1 sensitizes to endothelial dysfunction in hyperhomocysteinemic mice. Arterioscler. Thromb. Vasc. Biol. (2002) 22:1996-2002.
Raife, T.J., Rosenfeld, S.B., and Lentz, S.R. Bleeding from acquired coagulation defects and fibrinolytic therapy. In: Rossi’s Principles of Transfusion Medicine, 3rd ed. Simon, T.L., Dzik, W.H., Snyder, E., Stowell, C.P., and Strauss, R.G., editors. R.G. Lippincott Williams & Wilkens, Philadelphia. (2002) 399-414
Lentz, S.R. ATVB In Focus: a new series of focused brief reviews in Arteriosclerosis, Thrombosis, & Vascular Biology. Arterioscler. Thromb. Vasc. Biol. (2002) 22:1064
Hiatt, B.K and Lentz, S. R. Prothrombotic states that predispose to stroke. Current Treatment Options in Neurology (2002) 4:417-425
2001
Böger, R.H., Lentz, S.R., Bode-Böger, S.M., Knapp, H.R., and Haynes, W.G. Elevation of asymmetric dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inemia in humans. Clin. Sci. (2001) 100:161-167
Lentz, S. R. Piegors, D.J., Malinow, M.R., and Heistad, D.D. Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys. Circulation (2001) 103:1006-1011
Werstuck, G.H., Lentz, S.R., Dayal, S., Hossain, G.S., Sood, S.K., Shi, Y.Y., Zhou, J., Maeda, N., Krisans, S.K., Malinow, M.R., and Austin, R.C. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and fatty acid biosynthesis pathways. J. Clin. Invest. (2001) 107:1263-1273
Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Sigmund, C.D., Heistad, D.D., Faraci, F.M., and Lentz, S.R. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine b-synthase-deficient mice. Circ. Res. (2001) 88:1203-1209
Piette, W.W. and Lentz, S.R. Endothelial protein C activation in meningococcal sepsis (Letter). N. Eng. J. Med. (2001) 345:1776
Lentz, S.R. Homocysteine and cardiovascular physiology. In: Homocysteine in Health and Disease. Carmel, R. and Jacobsen, D.W., editors. R.G. Cambridge University Press, New York. (2001) 441-450.
Lentz, S.R. Does homocysteine promote atherosclerosis? Arterioscler. Thromb. Vasc. Biol. (2001) 21:1385-1386
2000
Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.
Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.
Böger, R.H., Bode-Böger, S.M., Heistad, D.D., Frolich, J.C. and Lentz, S.R. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1557-1564
Mudd, S.H, Finkelstein, J.D., Refsum, H., Ueland, P.M., Lentz, S.R., Jacobsen, D.W., Brattström, L., Wilcken, B., Wilcken, D.E.L., Blom, H.J., Stabler, S.P., Allen, R.H., Selhub, J., and Rosenberg, I.H. Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1704-1706
Lentz, S.R., Erger, R.A., Dayal, S., Maeda, N., Malinow, M.R., Heistad, D.D., and Faraci, F.M. Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine b -synthase-deficient mice. Am. J. Physiol. Heart Circ. Physiol. (2000) 279:H970-H975
Joyce, D.E, Piette, W.W., Stone, M.S., Carlisle, T.L., and Lentz, S.R. Severe acquired protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis. Thromb. Haemost. (2000) 84:929-930
Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.
Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.
Shrader, M. and Lentz, S.R. Electronic communication at Arteriosclerosis, Thrombosis, and Vascular Biology. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1851
1990-1999
Clements, J.L., Lee, J.R., Yang, B., Olson, J.D., Sandra, A., Lentz, S.R., and Koretzky,G.A. Fetal hemorrhage and platelet dysfunction in SLP-76 deficient mice. J. Clin. Invest. (1999) 103:19-25
Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1999 ed.
Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1999 ed.
Lentz, S.R., Fernandez, J.A., Griffin, J.H., Piegors, D.J., Erger, R.A., J.A., Malinow, M.R., and Heistad, D.D. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arterioscler. Thromb. Vasc. Biol. (1999) 19:1744-1750
Peterson, J.J., Rayburn, H.B., Lager, D.J., Raife, T.J., Kealey, G.P., Rosenberg, R.D., and Lentz, S.R. Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds. Am. J. Pathol. (1999) 155:1569-1575
Raife, T.J., Lager, D.J., Peterson, J.J., Erger, R.A., and Lentz, S.R. Keratinocyte-specific expression of human thrombomodulin in transgenic mice. Effects on epidermal differentiation and cutaneous wound healing. (1998) J. Investigat. Med. 46:127-133
Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1998
Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1998 ed.
Raife, T. J., McArthur, J., Peters, C., Kisker, C. T., and Lentz, S.R. Remission after 13-cis retinoic acid treatment in a case of refractory thrombotic thrombocytopenic purpura. Lancet (1998) 352:454-455
Lentz, S.R. Mechanisms of thrombosis in hyperhomocysteinemia. (1998) Current Opinion in Hematology 5:343-349
Raife, T. J., Olson, J.D, and Lentz, S.R. Platelet antibody testing in idiopathic thrombocytopenic purpura. (1997) Blood 89:1112-1113
Joyce, D.E., Chen, Y., Erger, R.A., Koretzky, G.A., and Lentz, S.R. Functional interactions between the thrombin receptor and the T cell antigen receptor in human T cell lines. (1997) Blood 90:1893-1901
Lentz, S.R., Malinow, M.R., Piegors, D.J., Bhopatkar-Teredesai, M., Faraci, F.M., and Heistad, D.D. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys. Arterioscler. Thromb. Vasc. Biol. (1997) 17:2930-2934
Heistad, D.D, Lentz, S.R., Hayreh, S.S., and Faraci, F.M. Cerebral vascular effects of atherosclerosis and homocysteine: potential target for gene therapy. In: Proceedings of the 20th Princeton Conference. Futura. (1997)
Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1997 ed.
Lentz, S.R. Homocysteine and vascular dysfunction. (1997) Life Sciences 61:1205-1215
Schlueter, A.J., Al-Jurf, A.S., and Lentz, S.R. Kung fu phlebitis: an unusual presentation of Mondor's disease. (1996) Am. J. Hematol. 52:66-67
Lentz, S.R., Sobey, C.G., Piegors, D.J., Bhopatkar, M.Y., Faraci, F.M., Malinow, M.R., and Heistad, D.D. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. (1996) J. Clin. Invest. 98:24-29
Raife, T.J., Demetroulis, E.M., and Lentz, S.R. Regulation of thrombomodulin expression by all-trans retinoic acid and tumor necrosis factor-a : differential responses in keratinocytes and endothelial cells. (1996) Blood 88:2043-2049
Newell, A.A, Raife, T.J., and Lentz, S.R. Interference in protein C activation assays from endogenous serpins in mammalian host cells. (1996) Thromb. Res. 84:373-377
Heistad, D.D, Lentz, S.R., and Rios, C.D. Atherosclerotic vascular disease: will folate or gene therapy be useful? Trans. Am. Clin. Climatol. Assoc. (1996) 108:69-77
Lager, D.J., Callaghan, E.J., Worth, S.F., Raife, T.J., and Lentz, S.R. Cellular localization of thrombomodulin in human epithelium and squamous malignancies. (1995) Am. J. Pathol. 146:933-943
Raife, T.J., Lager, D.J., Madison, K.C., Piette, W.W., Howard, E.J., Sturm, M.T., Chen, Y. and Lentz, S.R. Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. (1994) J. Clin. Invest. 93:1846-1851
Lentz, S.R. and Sadler, J.E. The molecular basis of thrombomodulin function. In: Thrombin, thrombomodulin, and the control of hemostasis. Giddings, J.C., editor. R.G. Landes Company, Austin, TX. (1994) 91-120
Lentz, S.R., Krewson, L, and Zutter, M.M. Recurrent neuroendocrine (Merkel cell) carcinoma of the skin presenting as marrow failure in a man with systemic lupus erythematosus. (1993) Med. Pediatr. Oncol. 21:137-141
Lentz, S.R. and Sadler, J.E. Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum. (1993) Blood 81:683-689
Lentz, S.R., Chen. Y., and Sadler, J.E. Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. (1993) J. Biol. Chem. 268:15312-15317
Sadler, J.E., Lentz, S.R., Sheehan, J.P., Tsiang, M., Wu, Q. Structure-function relationships of the thrombin-thrombomodulin interaction. (1993) Haemostasis 23
(suppl 1):183-193
Tsiang, M., Lentz, S.R., and Sadler, J.E. Functional domains of membrane-bound human thrombomodulin: EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. (1992) J. Biol. Chem. 267:6164-6170
Wu, Q., Tsiang, M., Lentz, S.R., and Sadler, J.E. Ligand specificity of human thrombomodulin: equilibrium binding of human thrombin, meizothrombin and factor Xa to recombinant thrombomodulin. (1992) J. Biol. Chem. 267:7083-7088
Lentz, S.R. Disorders of hemostasis. In: Manual of Medical Therapeutics, 27th ed. Woodley, M. and Whelan, A., editors. Little, Brown and Company, Boston. (1992) 323-340
Lentz, S.R., Tsiang, M., and Sadler, J.E. Regulation of thrombomodulin by tumor necrosis factor-a : comparison of transcriptional and posttranscriptional mechanisms. (1991) Blood 77:542-550
Wu, Q., Sheehan, J.P., Tsiang, M., Lentz, S.R., Birktoft, J.J., and Sadler, J.E. Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. (1991) Proc. Natl. Acad. Sci. USA 88:6775-6779
Lentz, S.R. and Sadler, J.E. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. (1991) J. Clin. Invest. 88:1906-1914
Lentz, S.R., Raish, R.J., Orlowski, E.P., and Marion, J.M. Squamous cell carcinoma in epidermolysis bullosa: treatment with systemic chemotherapy. (1990) Cancer 66:1276-1278
Tsiang, M., Lentz, S.R., Dittman, W.A., Wen, D., Scarpati, E.M., and Sadler, J.E. Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues. (1990) Biochemistry 29:10602-10612
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