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Molecular Mechanisms of Signaling in Myxococcus xanthus Development.
J Mol Biol. 2016 Jul 15;
Authors: Bretl DJ, Kirby JR
Myxococcus xanthus is an environmental bacterium that displays a complex lifecycle that includes motility, predation, multicellular fruiting body development, and sporulation. Given the elaborate fruiting body development of this bacterial species, M. xanthus has served as a model organism for the study of multicellular development of bacteria and a remarkable number of genes have been identified that contribute to the regulation of this highly dynamic process. Included amongst these developmental factors is a robust repertoire of signaling proteins, which have arisen from extensive gene duplication in M. xanthus and related species. In this review we explore several aspects of the molecular mechanisms of signaling in M. xanthus development. This includes mechanisms of kin selection, single cell sensing of nutrient depletion and the stringent response, the production of and response to extracellular population cues, and the contribution of several two-component signaling systems regulating developmental transcriptional programs. Collectively, these signaling mechanisms function to tightly regulate the sensing of nutrient depletion, the aggregation of populations of cells, and the temporal and spatial formation of complex fruiting bodies and sporulation of M. xanthus.
PMID: 27430596 [PubMed - as supplied by publisher]
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