Martin J. Richer, Ph.D.

Postdoctoral Fellow
martin-richer@uiowa.edu

Lab: 319-335-9919
Fax: 319-335-9006

Training

B.Sc. McGill University, Montreal, Canada
M.Sc. Université de Montréal, Montreal, Canada
Ph.D. The University of British Columbia, Vancouver, Canada

Research

CD8 T cells play a critical role in the immune response to intracellular pathogens. Understanding the factors that regulate both the quantity and the quality of CD8 T cell responses to infection may have important implications for the development of cancer therapies and effective vaccines. I am currently interested in characterizing the effects of inflammatory cytokines on the quality of effector and memory CD8 T cell responses to viral and bacterial infections.

Selected Publications Pubmed

1. Richer MJ, Nolz JC, and Harty JT (2012) Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8 T cells by enhancing TCR signaling.  Immunity 2013 Jan 24;38(1):140-52.
2. Condotta SA, Richer MJ, Badovinac VB and Harty JT (2012) Probing CD8 T Cell Responses with Listeria monocytogenes Infection. Advances in Immunology 2012;113:51-80. Review.
3. Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. (2012) Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS ONE 2012;7(2):e31153.
4. Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. (2009) Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. PLoS ONE. 2009;4(1):e4127. 
5. Richer MJ, Straka N, Fang D, Shanina I and Horwitz MS (2008) Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008 May;57(5):1302-11. 
6. Richer MJ, Fang D., Shanina I. and Horwitz MS. (2006) Toll-like Receptor 4-induced Cytokine Production Circumvents Protection Conferred by TGF-β in Coxsackievirus Mediated Autoimmune Myocarditis. Clinical Immunology. 121, (3), Dec 2006: 339-349.