Jeff Nolz, Ph.D.

Postdoctoral Research Fellow
jeffrey-nolz@uiowa.edu

Lab: 319-335-9919
Fax: 319-335-9006 

Training and Awards

2003 B.S. in Biological Sciences South Dakota State University 
2007 Ph.D. in Biomedical Sciences (Immunology) Mayo Clinic College of Medicine 
2009-2012 Career Development Award (Fellow) Leukemia and Lymphoma Society
2010 Future of Science Fund Scholarship Keystone Symposia-Viral Immunity
2011 Future of Science Fund Scholarship Keystone Symposia-New Frontiers at the Interface of Immunity and Glycobiology

Research

My current research interests lie in understanding the molecular mechanisms that regulate effector and memory T cell localization to different anatomical locations, which could ultimately result in enhanced vaccine design and improved immunotherapy techniques.

Publications Pubmed

1. Richer MJ, Nolz JC and Harty JT. Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8 T cells by enhancing TCR signaling.  Immunity.  2013 Jan 24;38(1):140-52. PMCID: PMC3557574 [Available on 2014/1/24]
2. Nolz JC, Rai D, Badovinac VP, Harty JT. Division-linked generation of ‘death-intermediates’ regulates the numerical stability of memory CD8 T cells. PNAS 2012 Apr 17;109(16):6199-204. PMC3341021
3. Nolz JC, Starbeck-Miller GR, Harty JT. Naïve, effector, and memory CD8 T cell trafficking: parallels and distinctions. Immunotherapy. 2011 Oct;3(10):1223-33. Review. PMC3214994
4. Nolz JC, Harty JT. Strategies and implications for prime-boost vaccination to generate memory CD8 T cells. Adv Exp Med Biol. 2012;780:69-83. Review.
5. Butler NS*, Nolz JC*, Harty JT Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol. 2011 Jul;13(7):925-33. Review. PMC3116979
6. Nolz JC, Harty JT. Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity. 2011 May 27;34(5):781-93. PMC3103642
7. Nolz JC, Nacusi LP, Medeiros RB, Mitchell JS, Shimizu Y, Billadeau DD. The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell Biol. 2008 Sep 22;182(6):1231-44. PMC2542481.
8. Nolz JC, Medeiros RB, Mitchell JS, Zhu P, Freedman BD, Shimizu Y, Billadeau DD. WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol. 2007 Sep;27(17):5986-6000. PMC1952166.
9. Nolz JC, Fernandez-Zapico ME, Billadeau DD. TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation. J Immunol. 2007 Jul 15;179(2):1104-12.
10. Billadeau DD, Nolz JC, Gomez TS. Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol. 2007 Feb;7(2):131-43. Review.
11. Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity. 2006 Jun;24(6):741-52. PMC1779661.
12. Nolz JC, Gomez TS, Zhu P, Li S, Medeiros RB, Shimizu Y, Burkhardt JK, Freedman BD, Billadeau DD. The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol. 2006 Jan 10;16(1):24-34. PMC1779663.
13. Nolz JC, Gomez TS, Billadeau DD. The Ezh2 methyltransferase complex: actin up in the cytosol. Trends Cell Biol. 2005 Oct;15(10):514-7.
14. Nolz JC, Tschumper RC, Pittner BT, Darce JR, Kay NE, Jelinek DF. ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotype. Leukemia. 2005 Jun;19(6):1018-24.
    
    *These Authors Contributed Equally