Marie Kim

Graduate Student, Interdisciplinary Graduate Program in Immunology
marie-kim@uiowa.edu 

Lab: 319-335-9919
Fax: 319-335-9006

Training

Undergraduate:
2009 B.S. University of California, Los Angeles
2009-present: University of Iowa Medical Scientist Training Program 

Research

Defining a new T death intermediate memory (Tdim) population, responsible for maintaining stable levels in the antigen-specific CD8 memory T cell pool  

Preliminary studies in our lab have shown a distinct population of non-functional memory T cells (Tdim) fated to undergo apoptosis. We have modeled that, to maintain a stable number in the memory pool despite proliferating central memory T cells (Tcm), one daughter cell from a proliferating Tcm or one non-proliferating cell must die per division, which we suspect are the Tdim population. We plan to isolate these two populations (Tdim and Tcm) for microarray studies to distinguish genes that may play a role in death signaling to Tdim cells.

Determining the T cell intrinsic v T cell extrinsic defect in proliferation of memory CD8 T cells with a history of repeated antigen exposure.  

Our lab has demonstrated that repeated antigen exposure profoundly impacts gene expression patterns in the resulting CD8 T cell memory compartment. Wirth et al analyzed whole-genome microarrays of memory cells with a precisely-defined antigen exposure history (primary to quaternary) that resulted in memory CD8 T cell populations with a unique repertoire of regulated genes and biological pathways. We plan to look at several genes of interest, such as CCR7, to better characterize the differential regulation of multiply antigen-stimulated CD8 memory T cells.

Publications

Xuan C, Kim M, Sieling PA, Sarno, EN, Rea TH, Smith T, Colonna M, Modlin RL, Lee DJ. A role for LILRA2 activation of monocytes in neutrophil recruitment during immune-mediated inflammation. Under Review.