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General Clinical Research Center
Laboratory Core |
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You won't find Dr. Jekyll or Mr. Hyde here, but you will find test
tubes and pipettes, electronic gadgets, and bitter solutions. |
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The GCRC Laboratory Core consists of the Analytical Laboratory Core
and the Physiology Laboratory Core. The purpose of the Laboratory Core
is to provide comprehensive and sophisticated analytical and
physiological capabilities to enhance and facilitate human research. |
Donna Farley and Suzan Hays review HPLC data.
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Analytical Laboratory Core
The laboratory is fully equipped
and routinely measures various peptides and hormones by high performance
liquid chromatography (HPLC), radioimmunoassay (RIA), enzyme
linked immunoassay (ELISA), and enzymatic colorimetry. |
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Current assays
that are routinely completed include cytokines (IL-6 and TNFa), leptin,
insulin, free fatty acids, c-reactive protein, angiotensin II,
catecholamines (norepinephrine, epinephrine and dopamine), and
homocysteine. Other specialized assays may be developed to meet the
changing needs of GCRC investigators. Current assays completed
by the laboratory along with sample collection procedures are listed
alphabetically (see assays and other
procedures).
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Physiology Core
The Physiology Core is comprised
of the bone physiology, pulmonary physiology, neural physiology,
cardiovascular physiology and vascular ultrasound laboratories. These
laboratories provide noninvasive and invasive methods for evaluating
physiologic responses under various conditions. The cardiovascular
physiology laboratory is equipped to measure resistance vessel
endothelial function, systemic hemodynamics and ambulatory 24-hour blood
pressure. The vascular ultrasound laboratory conducts vascular
ultrasound-Doppler and conduit vessel function studies.
The bone physiology laboratory is equipped to perform bone
densitometry studies and peripheral quantitative CT scans.
The pulmonary physiology laboratory is equipped to complete
pulmonary function testing, pulmonary exposure studies, and
functional CT imaging. The neural physiology laboratory performs
microneurographic recordings of efferent sympathetic nerve
activity to muscle and skin, as well as sympathetic stimulation
tests and recording of autonomic responsiveness using skin blood
flow.
For more information, contact:
Daryl J. (DJ) Murry, Pharm.D.
Director, GCRC Laboratory Core
Daryl-Murry@uiowa.edu
(319) 335-8157
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Ultrasound |
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Bone Physiology |
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Pulmonary Physiology |
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Cardiovascular Lab |
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