Biosciences Graduate Program

Nicholas Zavazava, MD, PhD

Portrait

Professor of Internal Medicine  - Immunology
Professor of Biomedical Engineering

Contact Information

Primary Office: C429-1 GH
Iowa City, IA 52242
Primary Office Phone: 319-384-6577

Email: nicholas-zavazava@uiowa.edu
Web: Departmental Profile

Education

BS, Universityof Rhodesia
MD, Universityof Kiel, Germany
PhD, Universityof Kiel, Germany

Fellowship, Clinical Immunology, University of Kiel, Germany
Fellowship, Clinical Chemistry, University of Kiel, Germany

Licensure and Certifications

Accreditation American Society for Histocompatability and Immunogenetics

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The work pursued in our laboratory primarily focusses on stem cells. We are interested in studying stem cell derived hematopoietic cell and insulin producing cells. Type 1 diabetes is one of the most devastating chronic diseases which costs billions of dollars every year. By establishing a stem cell based source of insulin producing cells, we might be able to treat many patients who would otherwise remain untreatable. Similarly, induced pluripotent stem cells are a novel source of hematopoietic cells for the treatment of leukemia and other hematopoietic malignancies. We have established nopvel approaches for the derivation of mouse and human hematopoietic cells. Our lab has several in vivo models for probing the efficacy of these cells in vivo.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases
Holden Comprehensive Cancer Center
Institute for Clinical and Translational Science

Selected Publications

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Kim E, Manzar G, Zavazava N.  Human iPS cell-derived hematopoietic progenitor cells induce T-cell anergy in in vitro-generated alloreactive CD8+ T cells..  Blood.  2013 June. 121(26):5167-75.
[PubMed]

Kim E, Stultz R, Bonde S, Zavazava N.  Embryonic stem cell-derived T cells induce lethal graft-versus-host disease and reject allogenic skin grafts upon thymic selection..  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.  2012 March. 12(3):600-9.
[PubMed]

Tabayoyong W, Salas J, Bonde S, Zavazava N.  HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells..  Journal of immunology (Baltimore, Md. : 1950).  2009 November. 183(9):5449-57.
[PubMed]

Berg M, Zavazava N.  Re-direction of Tumor-Relevant Peptides into the Soluble MHC Class I Variants: A New Strategy to Escape Immune-Surveillance.  FASEB J.  2003. 17(7 (Suppl)):C124-C125.

Freese A, Zavazava N.  HLA-B7 beta-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses..  Blood.  2002 May. 99(9):3286-92.
[PubMed]

Fändrich F, Lin X, Chai G, Schulze M, Ganten D, Bader M, Holle J, Huang D, Parwaresch R, Zavazava N, Binas B.  Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning..  Nature medicine.  2002 February. 8(2):171-8.
[PubMed]

Zavazava N, Krönke M.  Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes..  Nature medicine.  1996 September. 2(9):1005-10.
[PubMed]

Date Last Modified: 06/07/2014 - 21:56:23