Biosciences Graduate Program

John Wemmie, MD, PhD


Professor of Psychiatry
Professor of Molecular Physiology and Biophysics, Neurosurgery

Contact Information

Office: 1314 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
Office Phone: 319-384-3173

Web: John Wemmie Laboratory, Molecular Psychiatry Division


Foreign Study Program, Trinity College, Carmarthen, Wales, United Kingdom
BA, Chemistry, Central College, Pella, IA
Intensive Language Study, Intensive Russian Language, St. Petersburg State University, St. Petersburg, Russia
MD, The University of Iowa College of Medicine, Iowa City, IA
PhD, Physiology and Biophysics, The University of Iowa, Iowa City, IA

Residency, Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

ABPN Certification: Psychiatry American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

We recently found that the Acid Sensing Ion Channel, ASIC contributes to synaptic plasticity, learning and memory. ASIC is one of three mammalian members of the DEG/ENaC cation channel family in mammals that are transiently activated by low extracellular pH. ASIC channels are voltage-insensitive and share a large extracellular domain thought to serve as a receptor for extracellular stimuli. Disrupting ASIC in mice eliminated acid-evoked cation currents in central neurons and led to impaired hippocampal long-term potentiation (LTP), learning and memory. Our current research focuses on identifying the mechanism for ASIC activation in vivo, understanding the role of ASIC in synaptic plasticity, and establishing an uninterrupted link between ASIC channel activity and its behavioral impact.

Date Last Modified: 01/15/2015 - 09:21:24