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Director, Pappajohn Biomedical InstituteProfessor of Internal Medicine
- Pulmonary, Critical Care and Occupational MedicineProfessor of
Molecular Physiology and Biophysics,
Email: email@example.comWeb: Welsh Laboratory
MD, The University of Iowa
Residency, Internal Medicine, University of Iowa Hospitals and ClinicsFellowship, University of California, San FranciscoFellowship, University of Texas Medical School, Houston
Interdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in InformaticsInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
The Welsh laboratory emphasizes research in two main areas. The first is understanding the biology of cystic fibrosis (CF), a common lethal genetic disease, and developing new treatments. Cystic fibrosis is caused by mutations in the gene that encodes the CFTR anion channel. Welsh and his colleagues are learning how the CFTR anion channel is regulated and how mutations disrupt its function. They also focus on the pathogenesis of cystic fibrosis lung disease, learning how the loss of CFTR causes the bacterial airway infections and inflammation that destroy the lung. To test key hypotheses, they developed a porcine model of cystic fibrosis that develops all the hallmarks of the human disease. Their studies of this model are providing a new understanding of the disease and are aiding the development of novel therapies. The lab also studies the molecular biology and physiology of changes in brain pH and the effect on acid sensing ion channels and neural function. They are particularly interested in understanding the bases of fear memory and how that memory might be altered to treat people with PTSD.
Date Last Modified: 04/12/2016 -
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