Biosciences Graduate Program

Aliye Uc, MD

Portrait

Associate Professor of Pediatrics  - Gastroenterology
Associate Professor of Radiation Oncology

Contact Information

Primary Office: 2865 JPP
Iowa City, IA 52242
Primary Office Phone: 319-384-6032

Email: aliye-uc@uiowa.edu
Web: INSPPIRE Pediatric Pancreatitis Research Consortium

Education

MD, Medicine, Istanbul University School of Medicine, Istanbul, Turkey

Residency, Pediatrics, Hacettepe University Children's Hospital, Ankara, Turkey
Residency, PL3, Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Fellowship, Pediatric Gastroenterology, University of Iowa Children's Hospital, Iowa City, Iowa

Licensure and Certifications

Iowa Medical License
Turkey Permanent Medical License
American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
American Board of Pediatrics
FLEX
FMGEMS
Board Certification in Pediatrics, Turkey

Education/Training Program Affiliations

Biosciences Graduate Program
Free Radical and Radiation Biology Graduate Program

Research Summary

Dr. Uc is a Pediatric Gastroenterologist with clinical and research focus in Cystic Fibrosis (CF)-related pancreatic disease, and acute and chronic pancreatitis in children. Her laboratory focuses on dissecting the mechanisms of pancreatic damage and inflammation in CF pigs and development of gene therapies to the pig pancreas. She described that the CF pigs had an increased immune and inflammatory response in their pancreas that could be responsible of ongoing injury. She coauthored publications with Dr. Michael Welsh’s group describing the phenotype of CF pig model. She is collaborating with Drs. Engelhardt and Norris on better understanding the pathogenesis of CF-related diabetes (CFRD) using the CF pig and ferret models. She is also the chair and the founding member of INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cure) with the task of studying the epidemiology, etiology, natural history and outcomes of pediatric pancreatitis, a disease without clear diagnostic parameters and treatment alternatives in children. In this context, she is developing a data registry, sample repository, and longitudinal studies on pediatric pancreatitis. University of Iowa is the coordinating center for this NIH-funded multicenter study with 14 other centers providing patients, data and biological samples. This constitutes the first initiative to create a multi-center approach to systematically characterize pancreatitis in children.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases

Date Last Modified: 06/07/2014 - 21:56:23