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Professor of Internal Medicine
Primary Office: SE419 GHIowa City, IA 52242
Email: firstname.lastname@example.orgWeb: Departmental Profile
MBBS, Christian Medical College, Vellore, India
Residency, Internal Medicine, District General Hospital Sunderland UKResidency, Nephrology and Transplantation, Royal Hallamshire and Northern General Hospitals (University of Sheffield), Sheffield, U.K.Fellowship, Nephrology, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland Ohio
Medical LicenseGernal Medical Council Indian medical CoucilAmerican Baord of Internal Medicine, Subspecialty Boards in NephrologyAmerican Board of Internal MedicineNational Board of Medical Sciencesroyal college of Physicians UK MRCP
Interdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Our lab has two principal interests: the first, focuses on regulation of sodium transport in the collecting duct of the kidney which plays a major role in the regulation of volume homeostasis and hypertension. I study the transcriptional and post transcriptional regulation of the epithelial sodium channel, ENaC, and two proteins that interact with ENaC, a ubiquitin ligase Nedd4-2 and the kinase Sgk1. The second focuses on regulation of soluble Flt1, an anti- angiogenesis protein and the effect of soluble Flt1 on the glomerulus, where it appears to disrupt the glomerular capillary barrier and cause proteinuria. we have made several original observations about the genomic organization of Flt1, identified new alternate sFlt1 transcripts and described some aspects of the post transcriptional regulation of sFLT1 and of FLT1 ectodomain cleavage. Recently we described further regulation of FLT1 cleavage and reported that aspirin inhibits sFlt1 expression in trophoblasts.
Date Last Modified: 04/12/2016 -
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