Biosciences Graduate Program

Christie P. Thomas, MBBS


Professor of Internal Medicine  - Nephrology

Contact Information

Primary Office: SE419 GH
Iowa City, IA 52242
Phone: 319-356-4216

Web: Departmental Profile


MBBS, Christian Medical College, Vellore, India

Residency, Internal Medicine, District General Hospital Sunderland UK
Residency, Nephrology and Transplantation, Royal Hallamshire and Northern General Hospitals (University of Sheffield), Sheffield, U.K.
Fellowship, Nephrology, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland Ohio

Licensure and Certifications

Medical License
Gernal Medical Council
Indian medical Coucil
American Baord of Internal Medicine, Subspecialty Boards in Nephrology
American Board of Internal Medicine
National Board of Medical Sciences
royal college of Physicians UK MRCP

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Our lab has two principal interests: the first, focuses on regulation of sodium transport in the collecting duct of the kidney which plays a major role in the regulation of volume homeostasis and hypertension. I study the transcriptional and post transcriptional regulation of the epithelial sodium channel, ENaC, and two proteins that interact with ENaC, a ubiquitin ligase Nedd4-2 and the kinase Sgk1. The second focuses on regulation of soluble Flt1, an anti- angiogenesis protein and the effect of soluble Flt1 on the glomerulus, where it appears to disrupt the glomerular capillary barrier and cause proteinuria. we have made several original observations about the genomic organization of Flt1, identified new alternate sFlt1 transcripts and described some aspects of the post transcriptional regulation of sFLT1 and of FLT1 ectodomain cleavage. Recently we described further regulation of FLT1 cleavage and reported that aspirin inhibits sFlt1 expression in trophoblasts.

Date Last Modified: 09/08/2015 - 16:45:43