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Associate Professor of Molecular Physiology and BiophysicsAssociate Professor of
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BS, Cellular and Molecular Biology, University of WashingtonPhD, Biology, University of California, San Diego
Fellowship, Memorial Sloan-Kettering Cancer Center
Biosciences Graduate ProgramDepartment of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in Molecular and Cellular Biology
A central requirement for eukaryotic cell growth and function is the ability to transport and sort proteins. Defects in protein trafficking can lead to debilitating diseases such as cystic fibrosis and Alzheimer's disease. Much of protein transport in a cell occurs via coated transport vesicles. My laboratory's research interests focus on the molecular events involved in the formation of transport vesicles, the selection of cargo molecules into vesicles, and the cellular regulation of protein transport. We use the mammalian Golgi apparatus as a model system for these studies. Transport vesicles can be generated from Golgi membranes in a cell-free system, allowing a biochemical dissection of this process. Projects in the lab include the identification and characterization of novel proteins and phospholipids that play roles in cargo selection of vesicle formation, and an analysis of the role of the cytoskeleton in vesicular transport. A longer term goal of the laboratory is to understand how, once cellular components are properly transported and sorted, they can be assembled into complex cellular structures such as the axons and dendrites of neurons and the microvilli of epithelial cells.
Date Last Modified: 06/07/2014 -
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