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Associate Professor of Internal Medicine
- Cardiovascular Medicine
MD, North China Coal Medical College, Tangshan, Hebei, ChinaMS, Kunming Medical College, Kunming, Yunnan, China
Post Doctorate, National Institute on Aging, NIH, Baltimore, MD, USA
Interdisciplinary Graduate Program in Neuroscience
Our laboratory is interested in understanding the role of highly spatio-temporal localized Ca2+ signals, namely Ca2+ sparks, in normal cell function and diseases (e.g., heart failure, arrhythmias and other disease). We use state of the art techniques such as patch-clamp and laser scanning confocal microscopy in combination with genetic mouse models to investigate the cellular mechanisms of Ca2+ regulation and dysregulation. Specifically, we are studying 1) the structure-function relationship between t-tubule system and Ca2+ handling in normal and diseased hearts. In this project, we are testing our hypothesis that t-tubule remodeling plays critical role in Ca2+ release instability and therefore Ca2+-dependent arrhythmogenesis in cardiomyopathies; 2) molecular mechanisms of t-tubule remodeling in heart disease. We are actively searching for the molecules that control and regulate t-tubule organization in cardiomyocytes; 3) Local Ca2+ signaling and sinoatrial node automaticity. In the third project, we are testing our hypothesis that Ca2+ sparks are highly locally controlled in sinoatrial nodal cells and that dys-regulation of local Ca2+ signaling in SAN cells contributes to pacemaker dysfunction. Our research projects are funded by National Heart, Lung and Blood Institute, American Heart Association.
Date Last Modified: 04/12/2016 -
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