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Professor of Physical Therapy and Rehabilitation Science
Primary Office: 1-248 Medical Education BuildingIowa City, IA 52242
Primary Office Phone: 319-335-9791
Email: email@example.comWeb: Neurobiology of Pain Laboratory
BS, Physical Therapy, Georgia State University, Atlanta, GAPhD, Anatomy, University of Texas Medical Branch, Galveston, TX
Biosciences Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Pain, fibromyalgia, arthritis, immunology, ion channels, second messengers, glutamate, serotonin, fatigue. My research focuses on the peripheral and central neuronal mechanisms in the development and maintenance of musculoskeletal pain. We use animal models of acute and chronic musculoskeletal pain that produce behavioral signs such as limping and guarding of the limb and an increased response to noxious stimuli, hyperalgesia. Our laboratory is currently focusing on the acid sensing ion channels (ASICs) in the peripheral nervous system, and in synoviocytes lining the joint. We are also focusing on the supraspinal mechanisms underlying musculoskeletal pain including interactions between hyperalgesia and fatigue. Supraspinally we are examining brainstem and cortical sites involved in injury-induced pain behaviors with particular attention to the role of NMDA receptor subunits, phosphorylation of these subunits, and the serotonin system.
We have extended these studies and are examining the effects of regular physical activity (excercise) on the development of chronic muscle pain. We are examining central nervous system and immune system contributions to the analgesia produced by regular physical activity.
A third area of research has focused on deciphering the neurobiological mechanisms behind how transcutaneous electrical nerve stimulation (TENS) reduces pain. TENS is commonly used clinically as a non-invasive, adjunct therapy for pain control. Currently, we are translating findings from our animal laboratory to human subjects. We are currently performing a two-site clinical trial studying the efficacy of TENS in people with fibromyalgia.
Anatomical and Physiological Factors Contributing to Chronic Muscle Pain.
Animal Models of Muscle Pain.
An Overview of Animal Models of Pain: Disease Models and Outcome Measures..
HI-TENS Reduces Moderate-to-Severe Pain Associated with Wound Care Procedures: A Pilot Study..
Biol Res Nurs.
2013 August 15.
Frey Law L,
Fatigue-enhanced hyperalgesia in response to muscle insult: induction and development occur in a sex-dependent manner..
2013 July 29. 154(12):2668-76.
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin.
Int J Neurosci.
2013 July. 123(7):507-515.
What Makes Transcutaneous Electrical Nerve Stimulation Work? Making Sense of the Mixed Results in the Clinical Literature.
Effects of physical activity on laboratory pain: Studies on animals.
Taylor and Francis.
2013 June 5.
Assessment of avoidance behaviors in mouse models of muscle pain.
Widespread Chronic Pain: Underlying Mechanisms and Clinical Implications.
Date Last Modified: 09/23/2014 -
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