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Professor of Molecular Physiology and BiophysicsProfessor of
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BA, Biology (concentrations in biochemistry and microbiology), University of CaliforniaPhD, Biochemistry, University of California
Post Doctoral, Molecular Neurobiology, Dept. Medicine, UCSD
Biosciences Graduate ProgramDepartment of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.
Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels.
Date Last Modified: 06/07/2014 -
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