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Assistant Professor of Pharmacology
Primary Office: 3322 Pappajohn Biomedical Discover BuildingIowa City, IA 52242
Lab: 3322 Pappajohn Biomedical Discovery BuildingIowa City, IA 52242
Email: firstname.lastname@example.orgWeb: Potthoff Laboratory Website
BS, Suma Cum Laude, Biology / Zoology, University of OklahomaPhD, Genetics and Development, University of Texas Southwestern Medical Center
Fellowship, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
Interdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in Molecular and Cellular Biology
Nutrient Control of Hepatic Metabolism and Signaling
The regulation of metabolic homeostasis is a complex process coordinated by numerous growth factors and hormones signaling the availability of energy and nutrients. While it is well known that the liver functions to maintain energy homeostasis by producing energy sources for other cells during nutrient deprivation, the liver is also becoming recognized as a major regulator of systemic energy metabolism through production of hepatokines. These liver derived hormones signal nutrient availability to other tissues and control substrate utilization to maintain energy balance. My lab is interested in unraveling these hepatic pathways that govern systemic energy balance by focusing on known and novel hepatokines. The purpose is two-fold: 1) secreted factors are a rich source of new therapeutics because they are designed to circulate and signal, and 2) nutrient signaling is dysregulated in several diseases including diabetes and cancer. To identify and examine hepatokine function, my lab integrates biochemistry, proteomics, cell biology, metabolomics, and mouse genetics. By unraveling these liver-derived networks, we hope to identify a new therapeutic to treat obesity and metabolic disease.
Center for Gene Therapy of Cystic Fibrosis and other Genetic DiseasesFraternal Order of Eagles Diabetes Research Center
Colesevelam Suppresses Hepatic Glycogenolysis by TGR5-mediated Induction of GLP-1 Action in DIO Mice.
Am J Physiol: Gastrointestinal and Liver Physiol.
2013 February. 304(4):G371-G380.
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
2012 October 15. 1:e00065.
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
2012 February 15. 26(4):312-324.
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.
2011 June 8. 13(6):729-738.
Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.
2010 October 1. 143(1):35-45.
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
Am J Physiol Endocrinol Metab.
2010 June. 298(6):E1226-E1235.
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Proc Natl Acad Sci U S A.
2009 June 30. 106(26):10853-10858.
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.
J Clin Invest.
2008 November. 118(11):3588-3597.
MEF2: a central regulator of diverse developmental programs.
2007 December. 134(23):4131-4140.
Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c.
Mol Cell Biol.
2007 December. 27(23):8143-8151.
Date Last Modified: 11/19/2015 -
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