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Pediatric Hematology/Oncology Fellowship DirectorProfessor of Pediatrics
Primary Office: 2526 JCPIowa City, IA 52242
BS, Mathematics, cum laude, Creighton University, Omaha, NebraskaMS, Biochemistry, cum laude, University of Nebraska, Omaha, NebraskaPhD, Biochemistry, cum laude, University of Nebraska, Omaha, NebraskaMD, Medicine, cum laude, Ohio State University, Columbus, Ohio
Fellowship, Biochemistry, Ohio State University, Columbus, OhioFellowship, Medicine, Ohio State University, Columbus, OhioResidency, Pediatrics, Ohio State University, Columbus, OhioFellowship, Hematology/Oncology, Ohio State University, Columbus, Ohio
Biosciences Graduate ProgramInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Role of neuropeptides in development of neural crest derivatives.
Nervous system tumors are the most common cause of death from pediatric malignancies and rank second only to accidents as a cause of death in this age group. These cancers arise in the developing nervous system during fetal growth or infancy. Neuropeptides are important modulators of neurodevelopment and provide neuroprotection for stem cells and neurons. Vasoactive intestinal peptide is both a differentiation factor and a neuroprotective agent. Somatostatin is a potent modulator of growth factor release and also modulates the signal transduction pathway for multiple growth factors. We are studying the role of vasoactive intestinal peptide and somatostatin in neural development using transgenic and knock out mice. This new understanding of the role of neuropeptides in neural crest development should allow us to develop new diagnostic and therapeutic options for children with neuroblastoma and medulloblastoma.
Date Last Modified: 08/04/2015 -
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