Biosciences Graduate Program

David Murhammer, PhD

Portrait

Professor of Chemical & Biochemical Engineering

Contact Information

Office: 4132 SC
Iowa City, IA 52242
Office Phone: 319-335-228

Email: david-murhammer@uiowa.edu
Web: More About Dr. Murhammer - Related Websites and Resources

Education

BS, Chemistry, Oregon State University
MS, Chemical Engineering, Oregon State University
PhD, Chemical Engineering, University of Houston

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Human Toxicology

Research Summary

Viral Insecticide Production We are developing methods to produce viral insecticides in continuous systems that overcome accumulation of the few polyhedra (FP) mutants and defective interfering particles (DIP) characteristic of current continuous systems. DIP and FP mutant accumulation are being overcome by applying novel bioreactor designs and using molecular biology techniques, respectively. This research is being conducted in collaboration with investigators in the Department of Microbiology (College of Medicine) and the Department of Entomology at Iowa State University. Oxidative Stress We are investigating the oxidative stress resulting from the baculovirus infection of insect cells and the unique role of a baculovirus encoded Copper-Zinc Superoxide Dismutase homolog in this process. In a related project, the effect of carbon dioxide accumulation (which commonly occurs in large-scale bioreactors) on oxidative stress is also being investigated. This research has involved collaboration with groups in the Department of Free Radical & Radiation Biology (College of Medicine) and the Department of Molecular Biology at the University of Wyoming.

Date Last Modified: 06/07/2014 - 21:56:23