Biosciences Graduate Program

Michael K. Schultz, PhD

Portrait

Associate Professor of Radiology  - Division of Nuclear Medicine
Associate Professor of Internal Medicine, Radiation Oncology

Contact Information

Primary Office: B180 ML
Iowa City, IA 52242
Primary Office Phone: 319-335-8017

Email: michael-schultz@uiowa.edu

Education

BA, Russian Language, University of South Florida, Department of Linguistics, Tampa
MS, Marine Chemistry, Florida State University, Department of Oceanography, Tallahassee, FL
PhD, Chemical Oceanography, Florida State University

Fellowship, Graduate Researcher/Radiochemist (Predoctoral PhD Fellowship), National Institute of Standards and Technology, Gaithersburg, MD
Post Doctoral, Radiochemist (Postdoctoral, Targeted Radionuclide Therapy for Cancer Research), National Institute of Standards and Technology, Nuclear Medicine Program. Gaithersburg, MD

Education/Training Program Affiliations

Biosciences Graduate Program
Free Radical and Radiation Biology Graduate Program
Medical Scientist Training Program

Research Summary

ENVIRONMENTAL RADIOCHEMISTRY AND NUCLEAR FORENSICS RESEARCH

Dr Schultz leads the effort in the Department of Radiology and in collaboration with the Department of Chemistry to develop a broad curriculum and research agenda in radiochemistry. These efforts span a spectrum of applications involving the radiochemistry of the elements for understanding the impact of anthropogenic activities on environmental radioactivity, migration of radionuclides in terrestrial and aquatic environments, nuclear forensics, environmental science (geochronology), geochemistry and marine radiochemistry, as well as radiopharmaceutical research, nuclear medicine and cancer research. Dr Schultz has embarked on an intense focus on the potential environmental impact of hydraulic fracturing and unconventional drilling for natural gas and the potential for liberated radioactivity associated with these activities to impact the local environment and water resources. These efforts have lead to relevant findings concerning the geochemical fractionation of radionuclides in soils, sediments, and natural waters in field studies conducted in collaboration with the Savannah River and Oak Ridge National Laboratories, as well as the Ionizing Radiation Division at the National Institute of Standards and Technology.

DOE National Analytical Management Program
NAMP Radiochemistry Training Program
DOE NAMP Homepage
Schultz Lab Contributes to National Radiochemistry Webinar Series
Publications in Radiochemistry (Environmental and Nuclear Forensics)

PRECLINICAL CANCER RESEARCH - IMAGE-GUIDED THERAPY FOR METASTATIC MELANOMA

Dr Schultz's research involves developing a detailed understanding of differences in cancer cell metabolism and cell surface antigen expression - and exploiting these differences to develop novel image-guided therapies for cancer - with a focus on metastatic melanoma. This research focuses on differences in mitochondrial oxidative metabolism of metastatic melanoma cells relative to normal cells, which leads to identifiable metastatic-melanoma cell characteristics and antigen expression, which can be targeted for image-guided therapies using peptides and small molecules. The Schultz lab specializes in identifying these unique cancer-cell specific characteristics and synthesizing small molecules and peptides that target them for image-guided therapy for cancer. Within this context, the Schultz lab has identified and submitted provisional patents for a new class of cancer therapy drugs that target specific mitochondrial targets for therapy of metastatic melanoma. The Schultz lab has further identified two cell surface targets and accompanying peptide and small molecule targeting ligands that can be used for imaged-guided targeted radionuclide therapy for metastatic melanoma and is advancing these compounds toward clinical trials.

CLINICAL RESEARCH

Ga-68 Imaging of Pediatric NETs - 2nd World Congress on Ga-68 PET and PRRT
Molecular Imaging of Neuroendocrine Tumors

Institute for Clinical and Translational Science

ENTREPRENEURSHIP AND TECHNOLOGY TRANSFER

Dr Schultz is actively involved in entrepreneurial activities to move discoveries toward technology transfer and commercialization. His company, Viewpoint Molecular Targeting, LLC (www.viewpointmt.com) develops innovative image-guided therapies for cancer, with a focus on metastatic melanoma. The company recently secured resources through an agreement with strategic partner Radiomedix, Inc. (www.radiomedix.com), to begin preclinical imaging and biodistribution studies of newly discovered and co-developed agents in licensed facilities in Houston, TX. Company development activities and highlights include:

  • 2010 University of Iowa Fastrack Entrepreneurial Workshop (10 weeks)
  • 2011 $25,000 Grand Prize UI Business Plan/Elevator Pitch Competition
  • 2012 Keynote Address at the UI Entrepreneurial Bootcamp (CSO Michael K Schultz PhD)
  • 2013 $5,000 UI Innovation Summit Business Model Competition Award for Biotech Business Model Innovation
  • 2013 Distinguished Inventor Award, UI Innovation Summit (CSO Michael K Schultz PhD)
  • 2014 Phase I SBIR Award; Dr Schultz's company Viewpoint Molecular Targeting, LLC awarded collaborative Phase I SBIR (www.viewpointmt.com)

RADIOCHEMISTRY COMMUNITY SERVICE

1st World Congress on Ga-68
(Generators and Novel Radiopharmaceuticals), Molecular Imaging (PET/CT),
Targeted Radionuclide Therapy & Dosimetry (FWC-2011)
Dates: June 23-26, 2011
Bad Berka, Germany
Serving as: Scientific Advisory Committee

2nd World Congress on Ga-68
Complete Compilation of 2nd World Congress of Videotaped Oral Presentations
(Generators and Novel Radiopharmaceuticals), Molecular Imaging (PET/CT),
Targeted Radionuclide Therapy & Dosimetry (SWC-2013)
Dates: 28th February-2nd March, 2013
Chandigarh, India

Serving as: Conference Vice President
Conference Home Page

TEACHING IN RADIOCHEMISTRY

Dr Schultz is working with Assistant Professor Tori Forbes PhD in the Department of Chemistry to advance new curriculum in radiochemistry at the University of Iowa. These efforts have led to a new BA in Chemistry with a Radiochemistry Focus, as well as formalized coursework in radiochemistry that begins in the Fall Semester, 2013. For more information on the radiochemistry program at the University of Iowa, please contact Dr Schultz (michael-schultz@uiowa.edu) or Course Director Dr Tori Forbes PhD (tori-forbes@uiowa.edu) in the Department of Chemistry. Also see:

Degrees in Chemistry (including the BA Chemistry (Radiochemistry Focus)
Link: http://www.registrar.uiowa.edu/registrar/catalog/liberalartsandsciences/chemistry/

Curriculum in Radiochemistry
Link: https://isis2.uiowa.edu/isis2/courses/search.page?q.courseSubject=CHEM&q.courseNumber=4760&showResults=1

HONORS, AWARDS, GUEST RESEARCHER AFFILIATIONS AND ORGANIZATIONS

Fulbright Specialist Roster appointment for Radiochemistry (Awarded 07-05-2013). Dr Schultz has been appointed to the Fulbright Specialist Roster by the J William Fulbright Foreign Scholarship Board, the US Department of State's Bureau of Education and Cultural Affairs, and the Council for International Exchange of Scholars under the Fulbright Specialist Program (http://fulbright.ru). Dr Schultz will be working with Professor Lydia Bondareva (http://icmim.sfu-kras.ru/bondareva) and colleagues at Siberian Federal University (http://www.sfu-kras.ru) on curriculum development for environmental radiochemistry, nuclear forensics, and radiopharmaceutical science.

Nominated to the United States Environmental Protection Agency Science Advisory Board Radiation Advisory Committee (2014). This committee provides guidance to the United States Environmental Protection Agency on policy related to radioactivity in the environment.

Recent Invited Presentations (National and International)

  • Schultz MK and Nelson AW. (2014). American Chemical Society Annual Meeting. San Francisco, CA. Naturally-occurring radioactive materials and hydraulic fracturing in the United States.
  • Schultz MK and Nelson AW. (2014). National Environmental Monitoring Conference. Washington, DC. Naturally-occurring radioactive materials and hydraulic fracturing in the United States.
  • Schultz MK, De Vries DJ, & Forbes TZ. (2013). Development of an interdisciplinary curriculum in radiochemistry at the University of Iowa. Invited Paper and presentation. Nuclear Energy Global Meeting, July 29-Aug 1. Salt Lake City, UT.
  • Schultz MK. (2013). 2nd World Congress on Ga-68 Molecular Imaging and Peptide Targeted Radionuclide Therapy. Molecular imaging of pediatric patients with Ga-68 labeled peptides. Invited Presentation. February 27 – March 2, 2013.
  • Schultz MK. (2013). 2nd World Congress on Ga-68 Molecular Imaging and Peptide Targeted Radionuclide Therapy. Congress Highlights Presentation as Congress Vice President. February 27 – March 2, 2013. Chandigarh, India.
  • Schultz MK. (2012). Gordon Research Conference – Metals in Medicine. Radiochemistry and PET Imaging Applications of Generator Based Gallium-68. Invited Presenter. Andover, NH. June.
  • Schultz MK. (2012). Chelator additions to peptides for molecular imaging by ring strain promoted copper free click chemistry. Invited Faculty Continuing Education Seminar. Society of Nuclear Medicine Annual Meeting, Miami, FL. June 9.
  • Schultz MK. (2012). Molecular Imaging Advances for Pediatrics – [68Ga]DOTATOC and the horizon for PET imaging of pediatric cancers. Invited Faculty Presentation. Pediatric Council Meeting. Society of Nuclear Medicine Annual Meeting. Miami, FL. June 11.
  • Schultz MK. (2012). Radionuclides for Molecular Imaging and Therapy of Cancer. Invited Faculty Lecture, Oregon State University, Host Alena Paulenova, Professor of Radiochemistry. April, 2012.

Member, American Chemical Society
Guest Researcher, Oak Ridge National Laboratory
Member, American Association for the Advancement of Science
Member, Society of Nuclear Medicine (Pediatric Council 2007)
Member, International Society of Radiopharmaceutical Sciences
Fraternal Order of the Eagles (Iowa Aerie) Research Award - 2007
Fraternal Order of the Eagles (Iowa Aerie) Research Award — Childhood Cancer - 2009

RECENT PUBLICATIONS

RECENT INVITED PRESENTATIONS AND RELEVANT ABSTRACTS:

Date Last Modified: 07/23/2014 - 08:58:08