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Associate Professor of Molecular Physiology and BiophysicsAssociate Professor of
Ophthalmology and Visual Sciences
Office: 6-430 Bowen Science BuildingIowa City, IA 52242
Lab: 6-429 Bowen Science BuildingIowa City, IA 52242
BA, Biology, Luther CollegePhD, Physiology and Biophysics, University of Iowa
Fellowship, International Society for Eye Research TravelFellowship, National Eye Institute NRSAFellowship, The Jackson Laboratory
Department of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Research in my laboratory is aimed at understanding fundamental physiological properties of the eye and the pathophysiological mechanisms underlying a variety of complex eye diseases. Of primary interest are the glaucomas, a leading cause of blindness that affects approximately 70 million people worldwide. Glaucoma typically involves three types of events: molecular insults compromising the anterior chamber, increased intraocular pressure, and neurodegenerative retinal ganglion cell loss. Not surprisingly, the biological relationships linking these events are complex. Our approach for studying these events is founded in functional mouse genetics and supplemented by a variety of molecular, cellular, immunological, and neurobiological techniques. The premise for this approach is that stringently performed genetic studies offer great potential for overcoming the natural biological complexity of glaucoma. Current projects in the lab emphasize glaucoma phenotypes occuring in the front of the eye, including the molecular genetics of pigmentary glaucoma, exfoliative glaucoma, and central corneal thickness. We are also interested in new mouse models of glaucoma and have been studying an early onset form of glaucoma in nee mice that is associated with abnormalities of the aqueous drainage structures. In the long term, these studies will contribute to an increased understanding of eye diseases such as glaucoma, and ultimately to improved human therapies.
Stephen A. Wynn Institute for Vision Research
Blast Injury Exacerbates Neuropathology and Impairs Visual Function in a Transgenic APPswe-PSENd19e Mouse Model of AD [abstract].
Journal of Neurotrama.
Nano-scale morphology of melanosomes revealed by small-angle x-ray scattering.
Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis.
Pigment Cell Melanoma Res.
Circumferential iris transillumination defects in exfoliation syndrome.
van Duijn C,
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
Thomson Reuters ResearcherID on Web of Science: B-4580-2009.
Date Last Modified: 10/09/2015 -
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