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Associate Professor of Molecular Physiology and BiophysicsAssociate Professor of
Ophthalmology and Visual Sciences
Office: 6-430 Bowen Science BuildingIowa City, IA 52242
Office Phone: 319-335-7839
Lab: 6-429 Bowen Science BuildingIowa City, IA 52242
Email: email@example.comWeb: More information
BA, Biology, Luther College, Decorah, IAPhD, Physiology and Biophysics, University of Iowa, Iowa City, IA
Post Doctoral, Postdoctoral Fellow with Dr. Simon John, The Jackson Laboratory, Bar Harbor, ME
Biosciences Graduate ProgramDepartment of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Research in my laboratory is aimed at understanding fundamental physiological properties of the eye and the pathophysiological mechanisms underlying a variety of complex eye diseases. Of primary interest are the glaucomas, a leading cause of blindness that affects approximately 70 million people worldwide. Glaucoma typically involves three types of events: molecular insults compromising the anterior chamber, increased intraocular pressure, and neurodegenerative retinal ganglion cell loss. Not surprisingly, the biological relationships linking these events are complex. Our approach for studying these events is founded in functional mouse genetics and supplemented by a variety of molecular, cellular, immunological, and neurobiological techniques. The premise for this approach is that stringently performed genetic studies offer great potential for overcoming the natural biological complexity of glaucoma. Current projects in the lab emphasize glaucoma phenotypes occuring in the front of the eye, including the molecular genetics of pigmentary glaucoma, exfoliative glaucoma, and central corneal thickness. We are also interested in new mouse models of glaucoma and have been studying an early onset form of glaucoma in nee mice that is associated with abnormalities of the aqueous drainage structures. In the long term, these studies will contribute to an increased understanding of eye diseases such as glaucoma, and ultimately to improved human therapies.
Stephen A. Wynn Institute for Vision Research
Date Last Modified: 06/07/2014 -
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