Biosciences Graduate Program

Michael E. Wright, PhD

Portrait

Assistant Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 5-630 BSB
51 Newton Road
Iowa City, IA 52242
Primary Office Phone: 319-384-1764

Lab: 5-611C BSB
51 Newton Road
Iowa City, IA 52242
Phone: 319-384-1765

Email: michael-e-wright@uiowa.edu
Web: Wright Laboratory

Education

BS, Biology, Minor: Chemistry, University of Nevada
PhD, Molecular and Cellular Biology, University of Washington

Fellowship, Howard Hughes
Post Doctorate, University of Washington
Post Doctorate, United Negro College
Post Doctorate, Molecular Biotechnology, Department of Molecular Biotechnology and Institutes for Systems Biology

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Molecular Physiology and Biophysics PhD
Medical Scientist Training Program

Research Summary

My laboratory utilizes quantitative mass spectrometry to study signal transduction pathways in normal and diseased cells. We are studying how perturbations in androgen receptor signaling impacts disease progression in human prostate cancer. Our long-term goals are to build quantitative models of androgen-regulated signaling pathways in prostate cancer. We will use these models to understand the evolution and progression of hormone-refractory prostate cancers. We anticipate our findings will define new biomarkers of diagnostic, prognostic, or therapeutic value to patients afflicted by life-threatening hormone-refractory prostate cancers.

Selected Publications

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Hsiao J, Martinez H, Wright M.  Biochemical analysis of androgen receptor transcriptional complexes using quantitative mass spectrometry.  5th Great Lakes Nuclear Receptor Conference (GLNRC).  2012 November. 

Hsiao J, Martinez H, Wright M.  Quantitative Analysis of Androgen Receptor Transcriptional Complexes Using Directed Mass Spectrometry.  60th American Society for Mass Spectrometry Meeting.  2012 May. 

Wright M, Martinez H, Hsiao J, Jasavala R, Hinkson I, Eng J.  Androgen-sensitive Microsomal Signaling Networks Coupled to the Proliferation and Differentiation of Human Prostate Cancer Cells.  2011 October. 2(10):956-78.

Wright M.  Directed Mass Spectrometry: Molecular Dissection of Androgen Signaling Networks in Human Disease.  39th Great Lakes Joint American Chemical Society Meeting.  2011 October. 

Wright M.  Directed and Targeted Workflows For Studying Signaling Pathways and Validating Protein Biomarkers in Androgen Receptor-Related Diseases.  59th American Society for Mass Spectrometry Meeting.  2011 June. 

Wright M, Hsia D, Tepper C, Pochampalli M, Hsia E, Izumiya C, Huerta S, Chen H, Kung H, Izumiya Y.  KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.  2010. 107(21):9671-6.

Wright M, Hsiao J, Martinez H, Hinkson I, Jasavala R, Petersen T, Nesvizhskii A.  Androgen-sensitive factors modulate in androgen-receptor and androgen receptor mediated transcriptional outputs in prostate cancer. 

Wright M, Hsiao J, Martinez H, Smits M.  Androgen-sensitive Glycoprotein Networks Associated with the Proliferation and Adhesion of Prostate Cancer Cells. 

Wright M, Hsiao J, Jasavala R, Thumar J, Hwang S, Martinez H, Trimmer J, Han D.  CXCR7 Modulates Androgen Receptor Signaling Responses in Prostate Cancer Cells. 

Wright M, Hsiao J, Martinez H, Smits M.  Vesicle Protein Trafficking Regulates Androgen Receptor Signaling in Prostate Cancer Cells. 

Date Last Modified: 06/04/2015 - 08:51:49