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Assistant Professor of Molecular Physiology and Biophysics
Primary Office: 5-630 BSB51 Newton RoadIowa City, IA 52242
Primary Office Phone: 319-384-1764
Lab: 5-611C BSB51 Newton RoadIowa City, IA 52242
Email: email@example.comWeb: Wright Laboratory
BS, Biology, Minor: Chemistry, University of NevadaPhD, Molecular and Cellular Biology, University of Washington
Fellowship, Systems Biology, Institutes for Systems Biology
Biosciences Graduate ProgramDepartment of Molecular Physiology and Biophysics PhDMedical Scientist Training Program
My laboratory utilizes quantitative mass spectrometry to study signal transduction pathways in normal and diseased cells. We are studying how perturbations in androgen receptor signaling impacts disease progression in human prostate cancer. Our long-term goals are to build quantitative models of androgen-regulated signaling pathways in prostate cancer. We will use these models to understand the evolution and progression of hormone-refractory prostate cancers. We anticipate our findings will define new biomarkers of diagnostic, prognostic, or therapeutic value to patients afflicted by life-threatening hormone-refractory prostate cancers.
Quantitative Analysis of Androgen Receptor Transcriptional Complexes Using Directed Mass Spectrometry.
2012 May. Wright M,
Androgen-sensitive Microsomal Signaling Networks Coupled to the Proliferation and Differentiation of Human Prostate Cancer Cells.
2011 October. 2(10):956-78.
Directed Mass Spectrometry: Molecular Dissection of Androgen Signaling Networks in Human Disease.
2011 October. Wright M.
Directed and Targeted Workflows For Studying Signaling Pathways and Validating Protein Biomarkers in Androgen Receptor-Related Diseases.
2011 June. Wright M,
KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.
Androgen-sensitive factors modulate in androgen-receptor and androgen receptor mediated transcriptional outputs in prostate cancer.
Androgen-sensitive Glycoprotein Networks Associated with the Proliferation and Adhesion of Prostate Cancer Cells.
Biochemical analysis of androgen receptor transcriptional complexes using quantitative mass spectrometry.
CXCR7 Modulates Androgen Receptor Signaling Responses in Prostate Cancer Cells.
Vesicle Protein Trafficking Regulates Androgen Receptor Signaling in Prostate Cancer Cells.
Date Last Modified: 06/04/2015 -
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