Biosciences Graduate Program

James McNamara, PhD

Portrait

Associate Professor of Internal Medicine  - Hematology, Oncology and Blood and Marrow Transplantation

Contact Information

Lab: 5204 MERF
Iowa City, IA 52242

Email: james-mcnamara@uiowa.edu

Education

BS, Chemical Engineering, The University of Virginia, Charlottesville, VA
PhD, Neurobiology, Duke University, Durham, NC

Post Doctoral, Duke University Medical Center

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience

Research Summary

My lab develops RNA-based technologies to understand and treat disorders of the nervous system. We are using RNA aptamers (structural, artificial RNAs) that bind cell surface proteins expressed in the nervous system to directly activate signaling pathways, and to deliver siRNAs to specific cell types. We will apply these tools to elucidate mechanisms of disease in animal models and to develop novel therapeutic approaches. As part of this work, we are also developing novel RNA aptamer identification methodologies, including cell-based and whole animal-based aptamer screening approaches.

Date Last Modified: 07/22/2014 - 15:47:02