Biosciences Graduate Program

Wendy J. Maury, PhD

Portrait

Professor of Microbiology

Contact Information

Office: 3-750 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-8021

Lab: 3-701E Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Phone: 319-335-7613

Email: wendy-maury@uiowa.edu
Web: Carver College of Medicine Interview

Education

BA, Botany, Duke University
MS, Botany, North Carolina State University
PhD, Biology, University of Virginia

Post Doctoral, Molecular Microbiology, National Institutes of Health-NIAID
Post Doctoral, Virology, National Institutes of Health-NIAID

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

A goal of our research is to understand how enveloped viral glycoproteins bind to and mediate entry into permissive cells. An appreciation of the cellular attachment factors, receptors, internalization pathways and fusion events used by a virus to enter cells provides an avenue for the development of antiviral therapies. To this end, my laboratory primarily focuses on the filoviruses, Ebolavirus and Marburgvirus, but also investigates entry mechanisms of human immunodeficiency virus-1 (HIV-1). We have recently identified a novel cell surface receptor for filoviruses and are currently exploring the role of this family of cellular receptors in filovirus pathogenesis. In addition, studies in the lab have helped to elucidate the endosomal pathways used by filoviruses for entry and identified Ebola virus glycoprotein amino acids that are critical for productive Ebola virus infection. Stemming from this work are investigations into novel vaccine and antiviral therapeutic approaches designed to block filovirus infection.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Center for Immunology and Immune-based Diseases
Helen C. Levitt Center for Viral Pathogenesis
Holden Comprehensive Cancer Center

Selected Publications

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Moller-Tank S, Maury W.  Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection.  Virology.  2014 September 29. 468-470C:565-80.
[Link]

Moller-Tank S, Albritton L, Rennert P, Maury W.  Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry.  J Virol.  2014 June 15. 88(12):6702-13.
[Link]

Lennemann N, Rhein B, Ngundo E, Chandran K, Liu Q, Maury W.  Comprehensive functional analysis of N-linked glycans on Ebola virus GP1.  MBio.  2014 January 28. 5(1):e00862-13.
[Link]

Moller-Tank S, Kondratowicz A, Davey R, Rennert P, Maury W.  Role of the phosphatidylserine receptor TIM-1 in enveloped virus entry.  J Virol.  2013 August. 87(15):8327-41.
[Link]

Kondratowicz A, Hunt C, Davey R, Cherry S, Maury W.  AMP-Activated Protein Kinase Is Required for the Macropinocytic Internalization of Ebolavirus.  J Virol.  2013 January. 87(2):746-55.
[Link]

Brindley M, Hunt C, Kondratowicz A, Bowman J, Sinn P, McCray P, Quinn K, Weller M, Chiorini J, Maury W.  Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.  Virology.  2011 July 5. 415(2):83-94.
[Link]

Kondratowicz A, Lennemann N, Sinn P, Davey R, Hunt C, Moller-Tank S, Meyerholz D, Rennert P, Mullins R, Brindley M, Sandersfeld L, Quinn K, Weller M, McCray P, Chiorini J, Maury W.  T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.  Proc Natl Acad Sci U S A.  2011 May 17. 108(20):8426-31.
[Link]

Oh C, Price J, Brindley M, Widrlechner M, Qu L, McCoy J, Murphy P, Hauck C, Maury W.  Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.  Virol J.  2011 April 23. 8:188.
[Link]

Hunt C, Kolokoltsov A, Davey R, Maury W.  The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus.  J Virol.  2011 January. 85(1):334-47.
[Link]

Quinn K, Brindley M, Weller M, Kaludov N, Kondratowicz A, Hunt C, Sinn P, McCray P, Stein C, Davidson B, Flick R, Mandell R, Staplin W, Maury W, Chiorini J.  Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.  J Virol.  2009 October. 83(19):10176-86.
[Link]

Date Last Modified: 06/07/2014 - 21:56:23