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Associate Professor of Internal Medicine
- Cardiovascular MedicineAssociate Professor of
Office: Research Services 151 VAMCIowa City, IA 52242
Lab: 6W-29 Research Services, VA Med Center Iowa City, IA 52242
Email: email@example.comWeb: Internal Medicine
BS, Biology, University of Illinois at Urbana-ChampaignMS, Pharmacology, Medical College of WisconsinPhD, Medical College of Wisconsin
Post Doctorate, Cardiovascular Medicine, University of Iowa College of Medicine, Iowa City
The goal of the research in my laboratory is to further our understanding of the mechanisms involved in gender differences in vascular reactivity under normal conditions and diabetes. We have demonstrated that estrogen modulates contractility of the vasculature through regulation of calcium sensitivity of contractile proteins in smooth muscle. The ability of estrogen to modulate calcium sensitivity is mediated through the Rho/rho-kinase pathway. Estrogen modulates this pathway in diabetics as well to protect vasculature in female animals. We are currently focusing on the mechanisms responsible for estrogen regulation of the Rho/rho-kinase pathway. In addition, we are examining mechanisms responsible for the dysregulation in both Type 1 and Type 2 diabetics. Diabetes is a major risk factor for development of cardiovascular disease. Understanding mechanisms that contribute to vascular dysfunction in diabetes may provide clues for treatment to prevent the progression of cardiovascular disease.
Date Last Modified: 10/09/2015 -
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