Biosciences Graduate Program

Kevin Legge, PhD


Director, Department of Pathology Flow Cytometry Facility
Associate Professor of Pathology
Associate Professor of Microbiology

Contact Information

Primary Office: 1028 Medical Laboratories
Iowa City, IA 52242
Phone: 319-335-6744

Web: Dr. Legge's Research Laboratory


BS, University of Tennessee, Knoxville, TN
PhD, University of Tennessee, Knoxville, TN

Post Doctorate, Department of Microbiology, University of Tennessee, Knoxville, TN
Post Doctorate, Beirne B. Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA

Education/Training Program Affiliations

Department of Microbiology Graduate Program
Department of Pathology Graduate Program
Interdisciplinary Graduate Program in Immunology
Medical Scientist Training Program

Research Summary

Dendritic cell immunobiology and pulmonary immunity.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases
Holden Comprehensive Cancer Center

Selected Publications

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Zhao J, Zhao J, Legge K, Perlman S.  Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.  Journal of Clinical Investigation.  2011. 121(12):4921-30.

Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T.  The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.  Journal of immunology.  2011. 187(9):4581-8.

McGill J, Van Rooijen N, Legge K.  IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.  The Journal of experimental medicine.  2010. 207(3):521-34.

Langlois R, Meyerholz D, Coleman R, Cook R, Waldschmidt T, Legge K.  Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice.  Alcoholism, clinical and experimental research.  2010. 34(8):1425-31.

Langlois R, Legge K.  Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.  Journal of immunology.  2010. 184(8):4440-6.

McGill J, Legge K.  Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.  Journal of immunology.  2009. 183(7):4177-81.

McGill J, Meyerholz D, Edsen-Moore M, Young B, Coleman R, Schlueter A, Waldschmidt T, Cook R, Legge K.  Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.  Journal of immunology.  2009. 182(12):7803-8.

Brincks E, Katewa A, Kucaba T, Griffith T, Legge K.  CD8 T cells utilize TRAIL to control influenza virus infection.  Journal of immunology.  2008. 181(7):4918-25.

Meyerholz D, Edsen-Moore M, McGill J, Coleman R, Cook R, Legge K.  Chronic alcohol consumption increases the severity of murine influenza virus infections.  Journal of immunology.  2008. 181(1):641-8.

McGill J, Van Rooijen N, Legge K.  Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.  The Journal of experimental medicine.  2008. 205(7):1635-46.

Date Last Modified: 10/09/2015 - 15:23:31