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Assistant Professor of Pharmacology
Primary Office: 2-307 Bowen Science Building51 Newton Rd.Iowa City, IA 52242
Primary Office Phone: 319-353-5789
Lab: 2-300 Bowen Science Building51 Newton Rd.Iowa City, IA 52242
Email: firstname.lastname@example.orgWeb: Department of PharmacologyWeb: 2014 Faculty Focus interviewWeb: 2014 Press Release - Vasopressin in PreeclampsiaWeb: 2015 Press Release - Sodium & Weight Gain
BA, Chemistry, Hope College, Holland, MIBS, Biology, Hope College, Holland, MIPhD, Pharmacodynamics, University of Florida, Gainesville, FL
Postdoctoral Fellow, University of Florida, Physiology and Functional Genomics, Gainesville, FLPostdoctoral Fellow, University of Iowa, Internal Medicine, Iowa City, IA
Fellow of the American Heart Association (FAHA)
Biosciences Graduate ProgramDepartment of Pharmacology Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceMedical Scientist Training Program
My laboratory is generally focused on understanding neural control of cardiovascular and metabolic function. We employ a wide range of pharmacological and physiological methods, along with new genetically-modified animal models of health and disease. We currently focus on four major areas of inquiry:
1. The control of cardiovascular and metabolic function by the brain renin-angiotensin system. The renin-angiotensin system, a circulating hormone system that is very important for blood pressure control, is used in various tissues (e.g. - kidney, heart, adipose, brain) for paracrine/autocrine/intracrine signaling. One of our projects is aimed at mapping the neural circuitry that underlies the control of blood pressure and metabolic rate. Greater understanding of these mechanisms should lead to the development of novel therapeutics for obesity and obesity-hypertension.
2. The regulation of resting metabolic rate by the adipose renin-angiotensin system. Angiotensin peptides within adipose tissues act to suppress resting metabolic rate. We are working to clarify the effects of angiotensin peptides upon adipose tissue function, and the mechanisms involved. Clarification of these mechanisms may lead to completely new classes of anti-obesity therapeutics, which work through the stimulation of resting metabolic rate (a superior method, for which there are currently no safe drug options).
3. Improving methods of assessing resting metabolic rate in vivo / role of the gut microbiome in energy balance. Previously we recognized a need for improved methods to assess resting metabolic rate, as conventional methods (respirometry) are plagued with various shortcomings. Using advanced methods (combined direct calorimetry and respirometry) we have developed a method to assess non-aerobic metabolic processes in vivo, and determined that various interventions (anesthesia, modulation of angiotensin receptors, and high fat diet) differentially modulate aerobic vs. non-aerobic processes. Ongoing work is aimed at clarifying mechanisms by which the gut microbiome controls non-aerobic resting metabolism, and continuing development of superior technologies for metabolic assessment.
4. Investigating the role of vasopressin in the pathogenesis of preeclampsia. Preeclampsia is a cardiovascular disorder of late pregnancy that includes sudden increases in blood pressure, renal damage, and fetal damage. We recently discovered that elevated arginine vasopressin secretion is a useful very-early diagnostic for this disorder in humans, and infusion of this hormone can model the disorder in mice. Ongoing studies are designed to identify the causes for increased vasopressin secretion, and the receptors and second-messenger systems involved, to develop novel drugs to prevent or treat this disorder.
Cardiovascular Research CenterCenter for Functional Genomics of HypertensionFraternal Order of Eagles Diabetes Research CenterObesity Initiative
Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System.
2015 June 11. 5:11123.
Control of energy balance by the brain renin-angiotensin system.
Current hypertension reports.
2015 May 1. 17(5):38.
Vasopressin: The Missing Link for Preeclampsia?.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 March 25.
Vasopressin in Preeclampsia: A Novel Very-Early Human Pregnancy Biomarker and Clinically-Relevant Mouse Model.
2014 October. 64(4):852-859.
Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry.
Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice.
Am J Physiol: Endocrinol Metab.
2013 October 1. 305(7):E916-E924.
Siel Jr. R,
Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent.
Am J Physiol: Regul Integr Comp Physiol.
2013 May 15. 304(10):R818-R828.
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.
Am J Physiol Heart Circ Physiol.
2012 July 15. 303(2):H197-H206.
Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice.
2011 March. 57[Part 2}(3):600-607.
de Lange W,
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.
2010 November 3. 12(5):431-442.
Date Last Modified: 06/12/2015 -
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