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Professor of MicrobiologyProfessor of
Office: 3-530 Bowen Science Building51 Newton RdIowa City, IA 52242
Office Phone: 319-335-9720
Lab: 3-501B Bowen Science Building51 Newton RdIowa City, IA 52242
Email: email@example.comWeb: Harty Lab Website
BS, Biology, University of MinnesotaPhD, Microbiology, University of Minnesota
Post Doctorate, Scripps Clinical and Research Foundation, La Jolla, CAPost Doctorate, Howard Hughes Medical Institute, University of Washington
Biosciences Graduate ProgramDepartment of Microbiology Graduate ProgramInterdisciplinary Graduate Program in ImmunologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:
1. Regulation of memory T cell development
2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease
3. T cell homeostasis in response to infection
4. T cell mediated immunopathology after virus infection
5. CD8 T cell immunity against liver-stage malaria
Center for Immunology and Immune-based Diseases
IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.
J Clin Invest.
2014 March 3. 124(3):1013-26.
IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo.
J Exp Med.
2014 January 13. 211(1):105-20.
Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.
2013 November 14. 39(5):939-48.
Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling.
2013 January 24. 38(1):140-52.
Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.
Proc Natl Acad Sci U S A.
2012 April 17. 109(16):6199-204.
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.
2011 December 11. 13(2):188-95.
Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.
Cell Host Microbe.
2011 June 16. 9(6):451-62.
Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection.
2011 May 27. 34(5):781-93.
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.
2010 July 15. 6(7):e1000998.
Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.
Proc Natl Acad Sci U S A.
2010 July 6. 107(27):12198-203.
Date Last Modified: 06/07/2014 -
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