Biosciences Graduate Program

George J. Giudice, MA, PhD

Portrait

Professor of Dermatology

Contact Information

Office: 2080 Medical Laboratories
200 Hawkins Drive
Iowa City, IA 52242

Email: george-giudice@uiowa.edu
Web: Dermatology Department
Web: Immunology Graduate Program

Education

BS, Biology and Chemistry, High Honors, University of Illinois
MA, Biology, Princeton University, Princeton NJ
PhD, Cell Biology, Department of Biology, Princeton University, Princeton NJ

Fellowship, Biology Department/Malcom S. Steinberg Lab, Princeton University, New Jersey
Post Doctoral, NIH Molecular Genetics and Cell Biology, University of Chicago/Elaine V. Fuchs Lab

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

BP180, a protein expressed by keratinocytes in the basal layer of the epidermis, plays a prominent role in several skin diseases – both acquired and inherited – that are characterized by a detachment of the epidermis from the underlying basement membrane. Through the use of both in vivo and in vitro model systems, our laboratory has shown that autoantibodies against BP180 play a critical role in the pathogenesis of one such disease, bullous pemphigoid. We identified key factors in the multi-step pathogenic mechanism of this disease. Our recent work in collaboration with Dr. Janet Fairley (Head of Dermatology, U. Iowa) represents the first time a pathogenic role has been ascribed to a specific IgE class autoantibody in an autoimmune disease. Our studies of blistering skin diseases have provided insights into the structural and functional properties of the BP180 protein. Future directions for our lab include identifying BP180 interactor molecules, probing structure/function relationships within BP180, characterizing the cell signaling properties of this protein (both autoantibody-mediated and ligand-mediated), and using this information to develop novel diagnostic and therapeutic strategies for various disorders of the dermal-epidermal junction.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases

Selected Publications

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Van den Bergh F, Eliason S, Burmeister B, Giudice G.  Collagen XVII (BP180) modulates keratinocyte expression of the pro-inflammatory chemokine, IL-8.  Exp Dermatol.  2012 August. 21(8):605-611.
[Link]

Messingham K, Onoh A, Vanderah E, Giudice G, Fairley J.  Functional characterization of an IgE-class monoclonal antibody specific for the bullous pemphigoid autoantigen, BP180.  Hybridoma.  2012 April. 31(2):111-7.
[Link]

Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro S, An L, Giudice G, Diaz L, Senior R, Liu Z.  Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.  Matrix Biol.  2012 January. 31(1):38-44.
[Link]

Van Den Bergh F, Eliason S, Giudice G.  Type XVII collagen (BP180) can function as a cell−matrix adhesion molecule via binding to laminin 332.  Matrix Biol.  2011. 30(2):100-108.
[Link]

Date Last Modified: 09/18/2014 - 15:17:41