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Professor of Biology
Office: 246A BBIowa City, IA 52242
Email: email@example.comWeb: More About Dr. Slusarski - Related Websites and Resources
BA, Honors Biology, University of Illinois-UrbanaBS, Biochemistry, University of Illinois-UrbanaPhD, Biochemistry, Molecular/Cell Biology, Northwestern University
Post Doctorate, Biology, Johns Hopkins University
Interdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Development and Disease studies in Zebrafish
Progression from egg to embryo requires a dynamic interaction of signal transduction networks. We integrate in vivo image analysis coupled with molecular-genetic tools to elucidate the role of signaling networks critical in developmental processes and altered in human disease.
Manipulation of Calcium release induces dramatic alteration to body axis patterning and organogenesis, including heart and vasculogenesis in the zebrafish (Danio rerio). We have defined a class of secreted signaling ligands, called Wnts, which modulate calcium release. Wnts have key roles in development and disease and we are investigating the mechanisms by which the Wnt/calcium class mediates its biological effect on the developing embryo. Our developmental studies set the stage for investigations into vascular defects and tumor formation upon Wnt mis-regulation.
Due to remarkable conservation of developmental processes and mechanisms among vertebrates, we developed the zebrafish as a model for human disease including Bardet-Biedl syndrome (BBS). We have defined cardinal BBS features in zebrafish and currently, we are exploring genetic interactions, testing candidate genes and dissecting the molecular mechanisms of BBS function. In addition, we utilize the zebrafish in small molecule screens and retinal degeneration.
Date Last Modified: 04/12/2016 -
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