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Professor of Molecular Physiology and BiophysicsProfessor of
Obstetrics and Gynecology
Primary Office: 5-470 BSB51 Newton RoadIowa City, IA 52242
Lab: 5-471 BSB51 Newton RoadIowa City, IA 52242
BS, Biochemistry, Pennsylvania State College PhD, Biochemistry, Vanderbilt University
Fellowship, Reproductive Sciences Training GrantPost Doctorate, Endocrinology, Department of Medicine, Vanderbilt UniversityPost Doctorate, Foreign Researcher, INSERMFellowship, Department of Pharmacology, Vanderbilt University
Department of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
My laboratory studies the LH and FSH receptors, collectively termed the gonadotropin receptors. These G protein-coupled receptors (GPCRs) are predominantly expressed in the ovaries and testes where they each play pivotal roles in female and male reproductive physiology, respectively. We have been interested in the mechanisms governing the proper folding and cell surface expression of the gonadotropin receptors and how these processes are disrupted by loss-of-function mutations causing receptor misfolding. Our studies have also focused on elucidating the mechanisms underlying cell surface receptor activation by hormone agonists and by activating mutations of the receptors. We have recently demonstrated that the LH and FSH receptors can physically associate with themselves and with each other to form dimers and higher ordered oligomers. These complexes form early in the biosynthetic pathway and are not correlated with the activation status of the receptor. Current studies are addressing the potential functional ramifications of gonadotropin receptor homo- and hetero- associations. In a separate line of investigation initiated recently, we are also examining potentially novel physiological roles for the LH and FSH receptors in several non-gonadal tissues.
Date Last Modified: 10/09/2015 -
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