Biosciences Graduate Program

Deborah l. Segaloff, PhD

Portrait

Professor of Molecular Physiology and Biophysics
Professor of Obstetrics and Gynecology

Contact Information

Email: deborah-segaloff@uiowa.edu
Web: Departmental Profile

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My laboratory studies the LH and FSH receptors, collectively termed the gonadotropin receptors. These G protein-coupled receptors (GPCRs) are predominantly expressed in the ovaries and testes where they each play pivotal roles in female and male reproductive physiology, respectively. We have been interested in the mechanisms governing the proper folding and cell surface expression of the gonadotropin receptors and how these processes are disrupted by loss-of-function mutations causing receptor misfolding. Our studies have also focused on elucidating the mechanisms underlying cell surface receptor activation by hormone agonists and by activating mutations of the receptors. We have recently demonstrated that the LH and FSH receptors can physically associate with themselves and with each other to form dimers and higher ordered oligomers. These complexes form early in the biosynthetic pathway and are not correlated with the activation status of the receptor. Current studies are addressing the potential functional ramifications of gonadotropin receptor homo- and hetero- associations. In a separate line of investigation initiated recently, we are also examining potentially novel physiological roles for the LH and FSH receptors in several non-gonadal tissues.

Date Last Modified: 06/07/2014 - 21:56:23