Biosciences Graduate Program

Catherine A. Musselman, PhD

Portrait

Assistant Professor of Biochemistry

Contact Information

Primary Office: 4-452 BSB
Iowa City, IA 52242
Primary Office Phone: 319-335-7932

Email: catherine-musselman@uiowa.edu
Web: Musselman Laboratory

Education

BS, Chemistry, University of Colorado at Denver
MS, Chemistry, University of Michigan, Ann Arbor
PhD, Chemistry, University of Michigan, Ann Arbor

Fellowship, Chemistry, University of Colorado, Denver School of Medicine

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Biochemistry PhD

Research Summary

The genome of every eukaryotic cell resides in complex with histone proteins to form chromatin. Though originally thought to just package the genome into the nucleus, chromatin structure is now recognized to play an active role in the regulation of all DNA templated processes in eukaryotes. Such regulation requires the spatial and temporal alteration of chromatin structure, which is mediated by the chemical modification of histones and DNA as well as by the action of a large number of chromatin associated cofactors. My lab is interested in deciphering mechanisms of chromatin structure modulation and how misregulation of these pathways is associated with disease. Specifically, our goal is to elucidate, on the molecular level, the details of how cofactors target nucleosomes, especially in response to histone modification, and how this leads to the regulation of genes. Such knowledge will enhance our fundamental understanding of chromatin biology as well as reveal the etiology of many human diseases with the aim of eventually aiding in the development of targeted therapeutics. We employ NMR spectroscopy, X-ray crystallography as well as a variety of other biophysical and biochemical techniques to approach these questions.

Selected Publications

Show All

Musselman C, Avvakumov N, Watanabe R, Abraham C, Lalonde M, Hong Z, Allen C, Roy S, Nuñez J, Nickoloff J, Kulesza C, Yasui A, Côté J, Kutateladze T.  Molecular basis for H3K36me3 recognition by the Tudor domain of.  Natural Structure Molecular Biology.  2012 November 11. 19:1266-1272.
[Link]

Hagman J, Ramirez J, Dege C, Eshelman E, Musselman C, Kutateladze T.  Mi-2/NuRD chromatin remodeling complexes maintain transcriptional attenuation during B cell development.  Journal of Immunology.  2012 May 1. 188.

Musselman C, Ramirez J, Sims J, Mansfield R, Oliver S, Denu J, Mackay J, Wade P, Hagman J, Kutateladze T.  Bivalent Recognition of a Single Nucleosome by the Tandem PHD Fingers of CHD4 is Required for CHD4-Mediated Repression.  Biophysical Journal.  2012 January 31. 102(3):480a.

Musselman C, Ramirez J, Sims J, Mansfield R, Oliver S, Denu J, Mackay J, Wade P, Hagman J, Kutateladze T.  Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression.  Proceedings of the National Academy of Sciences.  2012 January 17. 109(3):787-792.
[Link]

Musselman C, Kutateladze T.  Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association.  Proceedings of the National Academy of Sciences.  2011 July 26. 108(30):12189-12190.
[Link]

Musselman C, Kwan A, Mansfield R, Mackay J, Kutateladze T.  The Tandem PHD Fingers of Chd4 Bind Synergistically to Histone H3.  Biophysical Journal.  2011 February 2. 100(3):67a.
[Link]

Chang P, Hom R, Musselman C, Zhu L, Kuo A, Gozani O, Kutateladze T, Cleary M.  Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.  Journal of Molecular Biology.  2010 July 9. 400(2):137-144.
[Link]

Hom R, Chang P, Roy S, Musselman C, Glass K, Selezneva A, Gozani O, Ismagilov R, Cleary M, Kutateladze T.  Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.  Journal of Molecular Biology.  2010 July 9. 400(2):145-154.
[Link]

Roy S, Musselman C, Kachirskaia I, Hayashi R, Glass K, Nix J, Gozani O, Appella E, Kutateladze T.  Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.  Journal of Molecular Biology.  2010 May 14. 398(4):489-496.
[Link]

Garske A, Oliver S, Wagner E, Musselman C, LeRoy G, Garcia B, Kutateladze T, Denu J.  Combinatorial profiling of chromatin binding modules reveals multisite discrimination.  Nature Chemical Biology.  2010 February 28. 6(4):283-290.
[Link]

Date Last Modified: 06/07/2014 - 21:56:23