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Professor of Internal Medicine
- Cardiovascular MedicineProfessor of
Molecular Physiology and Biophysics
Primary Office: 629 MRCIowa City, IA 52242
Primary Office Phone: 319-335-8958
BS, Biology/Chemistry, University of WisconsinPhD, Physiology, Louisiana State University Medical Center
Post Doctorate, Research, University of Iowa College of Medicine
Biosciences Graduate ProgramInterdisciplinary Graduate Program in Neuroscience
Dr. Chapleau's research focuses on mechanisms of autonomic regulation in health and disease including effects of aging, hypertension, hypercholesterolemia, cardiomyopathy, myocardial infarction (MI), heart failure, and muscular dystrophy. Key hypotheses involve the roles of acid-sensing ion channels in sensory transduction, reactive oxygen species and angiotensin in sensory and sympathetic signaling, and oxidative stress in autonomic dysregulation. Experimental approaches include assessment of the cellular and molecular basis of sensory transduction and neuronal excitability in baroreceptor and sympathetic neurons using patch-clamp, imaging, and molecular techniques; recording of baroreceptor and sympathetic nerve activity in vivo; and assessment of cardiovascular and autonomic function in conscious mice using radiotelemetry. The latter includes measurements of blood pressure, heart rate, locomotor activity, HR and BP variability, sympathetic and vagal tone, and baroreflex sensitivity.
1. Lu Y*, Ma X*, Sabharwal R*, Snitsarev V*, Morgan D, Rahmouni K, Drummond HA, Whiteis CA, Costa V, Price M, Benson C, Welsh MJ, Chapleau MW**, and Abboud FM**: The Ion Channel ASIC2 is Required for Baroreceptor and Autonomic Control of the Circulation. Neuron 64: 885-897, 2009. **Contributed equally to this paper. PMC2807410.
2. Sabharwal R, Zhang Z, Lu Y, Abboud FM, Russo AF, and Chapleau MW: Receptor Activity-modifying Protein-1 Increases Baroreflex Sensitivity and Attenuates Angiotensin-induced Hypertension. Hypertension 55: 627-635, 2010. PMC20100989.
3. Chapleau MW and Sabharwal R: Methods of Assessing Vagus Nerve Activity and Reflexes. Heart Fail Rev 16: 109-127, 2011.
4. Abboud FM, Harwani SC, and Chapleau MW: Autonomic Neural Regulation of the Immune System: Implications for Hypertension and Cardiovascular Disease. Hypertension 59: 755-762, 2012. PMC3313828.
Cardiovascular Research CenterGeorge M. O’Brien Kidney Research Center
Date Last Modified: 09/05/2014 -
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