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Director, ESR FacilityProfessor of Radiology Free Radical & Radiation Biology ProgramProfessor of Radiation Oncology in the Free Radical & Radiation Biology ProgramProfessor of Radiation OncologyProfessor of
Primary Office: B180K MLIowa City, IA 52242
Email: email@example.comWeb: More information
BA, Chemistry, University of Northern IowaMS, Chemistry, The University of IowaPhD, Chemistry, The University of Iowa
Fellowship, Radiation Research Lab, The University of IowaFellowship, NRSA, NIH/NIEHS North CarolinaFullbright Scholar, GSF Research Institute
Biosciences Graduate ProgramFree Radical and Radiation Biology Graduate ProgramInterdisciplinary Graduate Program in Human Toxicology
Dr. Buettner's research focuses on the basic chemistry and biology of free radicals and related oxidants in human health. His research program touches on many themes that include: The fundamental chemistry and biochemistry of vitamins C and E and other small molecular weight antioxidants. Work from his laboratory has played a major role in establishing the current paradigm of how these antioxidants function. This work has provided a new view of ascorbate as the terminal, small molecule, water-soluble antioxidant. See: The pecking order of free radicals and antioxidants: Lipid peroxidation, -tocopherol, and ascorbate. PMID: 8434935 and The ascorbate free radical as a marker of oxidative stress: An EPR study. PMID: 8384150.
Our work on ascorbate has lead to the hypothesis that ascorbate at physiological concentrations can be used as a pro-drug for the delivery of hydrogen peroxide to tumor cells and thereby serve as a component of the therapy of certain cancers. See: Ascorbic acid at pharmacologic concentrations selectively kills cancer cells: ascorbic acid as a pro-drug for hydrogen peroxide delivery to tissues. PMID: 16157892 and Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. PMID: 20068072.
Nitric Oxide as a membrane antioxidant. We have contributed to the understanding of fundamental chemistry of this small molecule functioning as and antioxidant. We have found that levels of only 10-50 micro molar are needed serve this function. See: Nitric oxide as a cellular antioxidant: A little goes a long way. PMID: 16443165.
We have initiated the new research field of Quantitative Redox Biology. This represents a transition from understanding basic biology of cells and tissues at an observational level to a true mechanistic level. Our work in this arena changed the working paradigm of redox biology. Examples are: The pecking order of free radicals and antioxidants: Lipid peroxidation, -tocopherol, and ascorbate. PMID: 8434935; Redox state of the cell as viewed though the glutathione disulfide/glutathione couple. PMID: 11368918; and A new paradigm: Manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. PMID: 17015180.
The primary goal of our research program is: to do some good.
Cardiovascular Research CenterCenter for Global and Regional Environmental ResearchEnvironmental Health Sciences Research CenterHolden Comprehensive Cancer CenterInstitute for Clinical and Translational Science
Ascorbic acid: Chemistry, biology and the treatment of cancer.
Biochimica et Biophysica Acta – Reviews on Cancer.
2012 December. 1826:443-457.
Date Last Modified: 08/04/2015 -
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