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Director, Child Neurology Residency ProgramFaculty Member, Interdisciplinary Program in Molecular BiologyFaculty Member, Medical Scientist Training ProgramFaculty Affiliate, Interdisciplinary Neuroscience ProgramProfessor of Pediatrics
- Neurology and Developmental and Behavioral PediatricsProfessor of
Primary Office: 2504 JCPIowa City, IA 52242
BS, Zoology, The University of IowaMD, The University of IowaPhD, Neuroscience, The University of Iowa
Post Doctorate, Combined Postdoctoral Fellowship in Neuroscience and Residency in Pediatrics, University of VirginiaResidency, Pediatric Neurology, University of Iowa
License to Practice Medicine and Surgery, Board of Medicine, Department of Health Professionals, Commonwealth of VirginiaLicense to Practice Medicine and Surgery, State Board of Medical Examiners, State of IowaFederal Licensing Examination (FLEX) Parts I and IIDiplomate, American Board of Psychiatry and Neurology, Certified in Neurology with Special Qualification in Child NeurologyDiplomate, American Board of Pediatrics
Biosciences Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
This laboratory investigates the biological mechanisms underlying neurologic birth defects. We are specifically interested in the brain injuries induced by lymphocytic choriomeningitis virus (LCMV) and by alcohol (fetal alcohol syndrome). In our studies of congenital LCMV infection, we utilize a rat model of the infection to study the cellular and molecular mechanisms underlying the virus-induced neuropathology. We are investigating the immune cell types and the cytokines involved in virus-induced neuronal death. In the developing brain, LCMV specifically infects certain neuronal populations and leaves others completely uninfected. We are studying the mechanisms by which LCMV spreads through the brain and are attempting to identify the metabolic and molecular characteristics of neurons that render them vulnerable to infection. Following infection with LCMV, both humans and the rats in our model system develop epilepsy. We are investigating the pathophysiology underlying this virus-induced epileptic condition. In our studies of fetal alcohol syndrome, we utilize animal models of the syndrome to study the mechanisms of alcohol-induced brain injury and the anatomical, histological and behavioral consequences of alcohol exposure. We have recently developed a mouse model of fetal alcohol syndrome, in which we utilize knock-out mice to study the importance of specific genes in influencing the pathological and behavioral effects of alcohol exposure.
Date Last Modified: 08/04/2015 -
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