Biosciences Graduate Program

Bryant F. McAllister, PhD

Portrait

Associate Professor of Biology

Contact Information

Office: 222 BB
Iowa City, IA 52242
Office Phone: 319-335-604

Email: bryant-mcallister@uiowa.edu
Web: More About Dr. McAllister - Related Websites and Resources

Education

BS, Zoology, Texas A & M University
MS, Genetics, Texas A & M University
PhD, Biology, University of Rochester

Post Doctoral, Molecular Evolution, UNIV OF CHICAGO
Post Doctoral, Molecular Evolution, UNIV EDINBURGH

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Neuroscience

Research Summary

Evolutionary Genetics and Genome Evolution My research interests are in the field of evolutionary genetics, especially in understanding processes occurring at or influenced by the genome. Active research projects in the lab are primarily focused on using the fly species Drosophila americana to identify the factors influencing chromosomal change and the mechanisms driving the differentiation of sex chromosomes. Changes in chromosomal arrangement are common, but their significance is unknown. We are currently examining a chromosomal rearrangement involving a centromeric fusion of the X chromosome and an autosome in D. americana (Fig. 1A) This derived arrangement exists as a polymorphism with the ancestral arrangement, showing a strong latitudinal cline in the central and eastern US. Studies are examining the hypothesis that these alternative chromosomal arrangements coordinate adaptive genetic variation. Independently evolved pairs of sex chromosomes exhibit similar patterns of differentiation. The Y chromosome is genetically inert, and the X chromosome contains many active unique genes and often compensates for differences in dosage between genders. The X-4 centromeric fusion in D. americana (Fig. 1A) provides a system for examining the earliest asymmetries between newly evolved sex chromosomes. We are testing models of sex chromosome evolution by examining patterns of sequence variation on this pair of neo-sex chromosomes.

Date Last Modified: 06/07/2014 - 21:56:23