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Associate Professor of Pediatrics
- Endocrinology and DiabetesAssociate Professor of
Primary Office: 1270B CBRBIowa City, IA 52242
Primary Office Phone: 319-335-7383
Email: email@example.comWeb: Norris Laboratory
BS, Chemistry, Massachusetts Institute of Technology, Cambridge, MassachusettsMD, Medicine, Washington University School of Medicine, St. Louis, MissouriPhD, Molecular Biology, Washington University School of Medicine, St. Louis, Missouri
Residency, University of Iowa Hospitals & Clinics, Iowa City, IowaFellowship, Children's Hospital Boston & Joslin Diabetes Center, Boston, MassachusettsPost Doctoral, Joslin Diabetes Center
Biosciences Graduate ProgramDepartment of Biochemistry PhDInterdisciplinary Graduate Program in Informatics
Our work is currently focused on three questions. (1) How does fetal over- or under-exposure to macronutrients incite poor metabolism? To study this, we have developed an in vivo fetal model accomplished via unilateral infusion of macronutrients into the uterine artery. (2) How does cystic fibrosis cause diabetes? We are working collaboratively with other University of Iowa investigators to better understand the pathophysiology of cystic fibrosis related diabetes. (3) How does direct action on skeletal muscle of the thiazolidinediones and their target, the transcription factor PPARgamma, help treat diabetes? We have recently demonstrated that PPARgamma directly augments the PDK1:AKT nexus of insulin signaling despite increasing muscle lipid uptake.
Center for Gene Therapy of Cystic Fibrosis and other Genetic DiseasesFraternal Order of Eagles Diabetes Research CenterObesity Initiative
Date Last Modified: 06/07/2014 -
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