Biosciences Graduate Program

Michael D. Abramoff, MD, PhD


Professor of Ophthalmology and Visual Sciences
Professor of Electrical & Computer Engineering, Biomedical Engineering

Contact Information

Primary Office: 11205  PFP
Iowa City, IA 52242
Primary Office Phone: 319-384-5833

Web: More About Dr. Abramoff - RELATED WEB SITES & RESOURCES
Web: NARCIS Netherlands Academic Research Network
Web: Researcher ID


MS, Medicine, University of Amsterdam
MS, Biomedical Informatics, University of Amsterdam
MD, Medicine, University of Amsterdam
PhD, Biomedical Imaging, University of Utrecht

Post Doctorate, Research Fellowship, RIKEN Neural Networks Research Laboratory
Residency, Surgery, University Hospital of Maastricht
Residency, Ophthalmology, University Hospital of Utrecht
Fellowship, Medical Retina, Vrije Universiteit University Hospital
Postgraduate Degree, Clinical Epidemiology Postgraduate Degree, Vrije Universiteit
Fellowship, Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics

Licensure and Certifications

State of Iowa Medical License, Iowa Board of Medicine
Netherlands Ophthalmology Certification, Netherlands Ophthalmologic Society (Netherlands Board of Ophthalmology)
USMLE I and II, ECFMG certification
Medical License, Netherlands

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The long range goal of Dr. Abramoff's research is to make computer aided diagnosis and digital retinal imaging for the screening, diagnosis and measurement of diabetic retinopathy, age related macular degeneration and glaucoma, patient friendly, low-cost and effective. These diseases are the big three causes of blindness in the US and most of the developing world, and screening and timely treatment is known to be effective or even cost-effective. Dr. Abramoff and his students and coworkers are developing novel methods for computer aided diagnosis and image analysis, retinal imaging at ultra wide field and ultra high resolution, image guided laser therapy of the retina. His research combines clinical ophthalmology, visual neuroscience and bioinformatics to study the phenotypes and genotypes of these diseases. Dr. Abramoff and coworkers have established large retinal imaging networks in the Midwest of the US and the Netherlands, with wide spread networks of retinal cameras connected through the internet to the University of Iowa, for screening of diabetic retinopathy. The tens of thousands of patients that are being image this way form the 'laboratory' for their research. Previously they have shown that computer aided diagnosis of diabetic retinopathy and glaucoma compares to retinal experts in small studies of hundreds of patients. They have developed image analysis algorithms that simulate the visual processing by the human brain to improve existing image analysis techniques, using for example computer simulations of simple and complex cell phase shifted gabor wavelet receptive fields. They are now starting to test the image processing algorithms on larger groups of patients collected through the network. Because computer aided diagnosis allows quantification of a retinal phenotype, preliminary studies are being performed to study the association of quantitative phenotype and genotype (SNP analysis) in age related macular degeneration and other retinal diseases in collaboration with the Carver Family Center for Macular Degeneration at the UI. An essential part of Dr. Abramoff's research is thus formed by an effective large scale network of high quality retinal imaging. Dr. Abramoff and coworkers have recently developed a patient-friendly, low cost camera, supported by an R01 from the NIH to build the network even more rapidly.

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration
Fraternal Order of Eagles Diabetes Research Center
Iowa Institute for Biomedical Imaging

Selected Publications

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Bogunovic H, Kwon Y, Rashid A, Lee K, Critser D, Garvin M, Sonka M, Abramoff M.  Relationships of retinal structure and Humphrey 24-2 visual field thresholds in patients with glaucoma.  Invest Ophthalmol Vis Sci.  2015. 56(1):259-271.

Abràmoff M, Wu X, Lee K, Tang L.  Subvoxel Accurate Graph Search Using Non-Euclidean Graph Space.  PLOS One.  2014 October. 9(10):e107763.

Antony B, Miri M, Abràmoff M, Kwon Y, Garvin M.  Automated 3D segmentation of multiple surfaces with a shared hole: Segmentation of the neural canal opening in SD-OCT volumes.  Med Image Comput Comput Assist Interv.  2014. 17(Pt. 1):739-746.

Bogunovic H, Sonka M, Kwon Y, Kemp P, Abràmoff M, Wu X.  Multi-surface and multi-field co-segmentation of 3-D retinal optical coherence tomography.  IEEE Trans Med Imaging.  2014. 33(12):2242-2253.

Springelkamp H, Lee K, Wolfs R, Buitendijk G, Ramdas W, Hofman A, Vingerling J, Klaver C, Abramoff M, Jansonius N.  Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma.  Invest Ophthalmol Vis Sci .  2014. 55(12):8428-8438.

Longmuir S, Oral R, Walz A, Kemp P, Ryba J, Zimmerman M, Abràmoff M.  Quantitative measurement of retinal hemorrhages in suspected victims of child abuse.  Journal of AAPOS.  2014. 18(6):529-533.

Abràmoff M, Folk J, Han D, Walker J, Williams D, Russell S, Massin P, Cochener B, Gain P, Tang L, Lamard M, Moga D, Quellec G, Niemeijer M.  Automated analysis of retinal images for detection of referable diabetic retinopathy.  JAMA Ophthalmol.  2013 March 1. 131(3):351-7.

Wahle A, Lee K, Harding A, Garvin M, Niemeijer M, Sonka M, Abràmoff M.  Extending the XNAT archive tool for image and analysis management in ophthalmology research.  Proc SPIE Med Imag.  2013 February 14. 8674:86740M.

Christopher M, Tang L, Fingert J, Scheetz T, Abràmoff M.  Changes in quantitative 3D shape features of the optic nerve head associated with age.  Proceedinsg SPIE Medical Imaging 2013: Computer-Aided Diagnosis .  2013 February 13. 8670:86700O.

Tang L, Niemeijer M, Reinhardy J, Garvin M, Abràmoff M.  Splat feature classification with application to retinal hemorrhage detection in fundus images.  IEEE Trans Med Imaging.  2013 February. 32(2):364-75.

Date Last Modified: 06/07/2014 - 21:56:23