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Mentor: David Wiemer, PhD
Year Entered Into Program: 2004
PhD Institution: University of Iowa, 2008
The focus of my research is the synthesis of the schweinfurthins and related natural products (e.g. vedelianin) that have potential as anticancer agents. Both enantiomers of 3-deoxy-5-methoxyvedelianin have been synthesized and determined to have significant cytotoxicity in the NCI’s 60 cell line assay (0.41 µM and 0.13 µM, respectively). Interestingly, the activity profile of the R,R,R-enantiomer does not match that of the S,S,S-enantiomer, leaving open the possibility that the two enantiomers work at different targets and/or by a different mechanism of action. Work continues on the development of analogs designed to increase the potency and illuminate what is believed to be a novel mechanism of cytotoxicity.
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