Pharmacology

Hayes Michael P.

Michael Hayes

Address: S338 PHAR
Phone: (319) 335-7845
Email: michael-p-hayes@uiowa.edu

Mentor: David Roman, PhD

Undergraduate Institution: Illinois State University, Norman, IL, BS

Year Entered Into Program: 2012

Affiliations

  • Medicinal and Natural Products Chemistry

Research Description

Prostate cancer is the most prevalent form of cancer in males with over 200,000 new cases diagnosed each year leading to over 25,000 deaths. Prostate cancer is notorious for metastasizing making the development of anti-prostate cancer therapeutics an area of intense research. G protein coupled receptors (GPCRs) are the molecular targets of nearly 40% of drugs currently on the market, and with the University of Iowa High Throughput Screening Facility, the ability to identify and characterize small molecules as potential therapeutics in a high throughput manner is now readily available. The main goal of my research is to design high throughput methodologies to develop molecular probes to further investigate the roles of GPCRs in prostate cancer. Thus far, assay design and miniaturization has been accomplished using optical label-free biosensing, fluorescent dye assays, and genetically encoded reporter proteins in both prostate cancer-derived cell lines and HEK cells.

Award(s)

  • AFPE Pre-Doctoral Fellowship, 2014-2015