Stead Family Department of Pediatrics

Michael Shy, MD


Attending Neurologist
Specialty: Neuromuscular Disease
Director, Division of Neuromuscular Medicine, Neurology
Professor of Neurology
Professor of Pediatrics, Molecular Physiology and Biophysics

Contact Information

Office: 2157 RCP
Iowa City, IA 52242
Phone: 319-384-5094



BA, History, University of Pennsylvania
MD, Medicine, Albany Medical College

Internship, Internal Medicine, Albany Medical Center
Residency, Columbia Presbyterian Medical Center
Fellowship, Clinical Neuroscience Training Program, Columbia Presbyterian Medical Center
Fellowship, Neuroimmunology, Muscular Dystrophy Association

Licensure and Certifications

Iowa MD license
Michigan MD license
Board Certified in Neurology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

My professional interests involve translational research to develop rational therapies for patients with inherited peripheral neuropathies and related neurodegenerative diseases.

Selected Publications

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Pisciotta C, Bai Y, Brennan K, Wu X, Grider T, Feely S, Wang S, Moore S, Siskind C, Gonzalez M, Zuchner S, Shy M.  Reduced neurofilament expression in cutaneous nerve fibers of patients with CMT2E..  Neurology.  2015 July 21. 85(3):228-34.

Patzkó A, Bai Y, Saporta M, Katona I, Wu X, Vizzuso D, Feltri M, Wang S, Dillon L, Kamholz J, Kirschner D, Sarkar F, Wrabetz L, Shy M.  Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice..  Brain : a journal of neurology.  2012 December. 135(Pt 12):3551-66.

Shy M, Prada V, Passalacqua M, Bono M, Luzzi  P, Scazzola S, Nobbio L, Capponi  S, Bellone E, Mandich P, Mancardi G, Schenone A, Grandis M.  Gain of glycosylation: a new pathomechanism of myelin protein zero mutations.  Annals of neurology.  2012. 71:427-431.

Shy M.  Lessons from London. Journal of neurology, neurosurgery, and psychiatry.  2012. 

Shy M, Saporta M, Shy B, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E, Saveri P, Kirschner  D, Crowther M, Southwood C, Wu X, Gow A, Feltri M, Wrabetz L.  MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B.  Brain.  2012. 135:2032-2047.

Shy M, Burns J, Ramchandren S, Ryan M, Ouvrier R.  Determinants of reduced health related quality of life in pediatric inherited neuropathies.  Neurology.  2010. 75:726-731.

Shy M, Kamholz J, Brucal M, Li J.  Myelin Protein Zero and CMT1B: a tale of two phenotypes.  Elsevier Press.  2007. 

Paulson H, Garbern J, Hoban T, Krajewski K, Lewis R, Fischbeck K, Grossman R, Lenkinski R, Kamholz J, Shy M.  Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease..  Annals of neurology.  2002 October. 52(4):429-34.

Shy M, Paulson H, Hoban T, Krajewski K, Garbern J, Lewis  R, Fischbeck K, Grossman R, Kamholz J.  Transient CNS white matter abnormality in X-linked Charcot-Marie-Tooth disease.  Ann Neurol.  2002. 52:429-434.

Shy M, Bird S, Brown M, Scherer S.  Autoimmune Demyelination Neuropathy Associated With Malignant Melanoma.  Neurology.  1996. 46:822-824.

Date Last Modified: 08/27/2015 - 13:23:08