Stead Family Department of Pediatrics

John Manak, PhD

Portrait

Associate Professor of Biology
Associate Professor of Pediatrics  - Nephrology, Dialysis and Transplantation

Contact Information

Office: 459A BB
Iowa City, IA 52242
Office Phone: 319-335-0180

Email: john-manak@uiowa.edu
Web: More About Dr. Manak - Related Websites and Resources

Education

BS, Biology, Trinity College
MS, Molecular Biology/Biochemistry; Cell/Developmental, New York University
PhD, Molecular Biology, Columbia University

Post Doctoral, Developmental Genetics, Stanford University
Post Doctoral, Molecular Genetics, Stanford University

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Summary

Research in my laboratory covers four different but not mutually exclusive areas: 1) fruit fly models to understand human diseases such as epilepsy and cancer, 2) high-throughput genomics technologies to identify the genetic basis of human disease, 3) genomic technology development to facilitate identification of important mutations and novel transcript isoforms in both humans and model organisms, and, 4) whole-genome transcriptome and chromatin analysis in established and emerging model organisms. Over the last few years, I have focused a significant portion of my efforts on the genetics/genomics of human disease. These efforts have resulted in discovery of new spina bifida and cleft lip and palate candidate genes, as well as a recombination hotspot associated with BOR (Branchio-Oto-Renal syndrome). We have also discovered that the same gene (prickle) mutated in flies, mice and humans causes epilepsy and we are elucidating the mechanism of epilepsy in our fly model.

Date Last Modified: 08/14/2013 - 12:06:53