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Professor of BiologyProfessor of
Office: 238 BBEIowa City, IA 52242
Email: email@example.comWeb: More About Dr. Green - Related Websites and Resources
BS, Biochemistry, University of Wisconsin-MadisonPhD, Biology, California Institute of Technology
Biosciences Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
We investigate the molecular and cellular mechanisms by which synaptic activity affects neuronal survival and the formation and stability of synapses. This investigation involves several distinct but overlapping projects. We use the auditory system for most of these projects because it is especially suitable for investigation of the role of synaptic activity in regulating neuronal survival and synapses. Activity in the cochlea (the auditory portion of the inner ear) depends entirely on the auditory sensory cells (“hair cells”). Hair cells can be selectively killed by administration of aminoglycoside antibiotics, allowing investigation of the consequence to the cochlear neurons (also called “spiral ganglion neurons”) of loss of their sole input. The loss of hair cells results in a rapid loss of the synaptic structure of the spiral ganglion neurons (SGNs), followed by gradual death of the SGNs. Several projects in the lab investigate molecular events in the SGNs following hair cell loss. These studies use a combination of techniques to identify those molecular events directly related to neuronal survival and death. These include in vivo studies of rats in which the intracochlear environment is manipulated and of transgenic mice. To complement these in vivo studies, we use physiological, biochemical, and gene transfer techniques for experimental studies of cultured rat and mouse SGNs. Taking advantage of our ability to perturb hearing in animals and to experimentally manipulate neurons using molecular and genetic techniques, we also investigate the role of activity and neurotrophic factors in synapse formation in the developing auditory cortex in the brain. In collaboration with other investigators at UI, we conduct parallel studies on other brain regions. Our studies of the role of neural activity in the cochlea are directly relevant to the cochlear implant, a highly effective neural prosthesis that is currently the only treatment for deafness.
Center for Auditory Regeneration and Deafness
Date Last Modified: 08/04/2015 -
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