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Professor of Molecular Physiology and BiophysicsProfessor of
Ophthalmology and Visual Sciences
Office: 5-532 Bowen Science BuildingIowa City, IA 52242
Office Phone: 319-335-7864
Lab: 5-533 Bowen Science BuildingIowa City, IA 52242
Email: email@example.comWeb: More information
BS, Biotechnology, St. Petersburg Institute of TechnologyPhD, St. Petersburg Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Biosciences Graduate ProgramDepartment of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
"Heterotrimeric GTP-binding proteins (G-proteins) are used by cells to transduce signals from the extracellular environment through surface receptors to intracellular effector proteins. One of the best model systems for studying mechanisms of G protein signaling is the rod photoreceptor visual transduction cascade. Our laboratory focuses on investigation of specific protein-protein interactions between the photoreceptor – rhodopsin, the rod G protein - transducin, and the effector enzyme - cGMP-phosphodiesterase. We study the modulation of transducin by retinal regulators of G protein signaling (RGS) and other accessory proteins. To understand the activation and turn-off mechanisms of transducin and cGMP-phosphodiesterase upon transduction of a visual signal we employ tools and techniques such as transgenic animal models, site-directed mutagenesis, synthetic peptides, site specific antibodies, cross-linking, and fluorescence spectroscopy.
The high levels of sequence homology between different types of G proteins, as well as the structural similarities observed in their crystal structures suggest that numerous G protein signaling systems have similar mechanisms of activation. Our ultimate goal is to understand the mechanisms of regulation of G protein signaling at the molecular level."
PubMed link to publications:
Date Last Modified: 07/31/2013 -
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